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Model Algorithms for Estimates of Inhalation Exposure and Comparison between Exposure Estimates from Each Model
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흡입 노출 모델 알고리즘의 구성과 시나리오 노출량 비교

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Type
Academic journal
Author
Park, Jihoon (한국과학기술연구원 유럽연구소 환경안전성연구단) Yoon, Chungsik (서울대학교 보건대학원 환경보건학과, 보건환경연구소)
Journal
Korean Industrial Hygiene Association 한국산업보건학회지 한국산업보건학회지 제29권 제3호 KCI Accredited Journals
Published
2019.1
Pages
358 - 367 (10page)

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Model Algorithms for Estimates of Inhalation Exposure and Comparison between Exposure Estimates from Each Model
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Objectives: This study aimed to review model algorithms and input parameters applied to some exposure models and to compare the simulated estimates using an exposure scenario from each model. Methods: A total of five exposure models which can estimate inhalation exposure were selected; the Korea Ministry of Environment(KMOE) exposure model, European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment(ECETOC TRA), SprayExpo, and ConsExpo model. Algorithms and input parameters for exposure estimation were reviewed and the exposure scenario was used for comparing the modeled estimates. Results: Algorithms in each model commonly consist of the function combining physicochemical properties, use characteristics, user exposure factors, and environmental factors. The outputs including air concentration ($mg/m^3$) and inhaled dose(mg/kg/day) are estimated applying input parameters with the common factors to the algorithm. In particular, the input parameters needed to estimate are complicated among the models and models need more individual input parameters in addition to common factors. In case of CEM, it can be obtained more detailed exposure estimates separating user's breathing zone(near-field) and those at influencing zone(far-field) by two-box model. The modeled exposure estimates using the exposure scenario were similar between the models; they were ranged from 0.82 to $1.38mg/m^3$ for concentration and from 0.015 to 0.180 mg/kg/day for inhaled dose, respectively. Conclusions: Modeling technique can be used for a useful tool in the process of exposure assessment if the exposure data are scarce, but it is necessary to consider proper input parameters and exposure scenario which can affect the real exposure conditions.
#Exposure model #inhalation #aerosol #algorithm #exposure scenario

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References (23)

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BAuA (German Federal Institute for Occupational Safety and Health) / SprayExpo: modelling exposure during spray applications-Predicting levels of inhalation and dermal exposure to aerosols with spray applications google schola Bekker C / 2014 / Airborne manufactured nano-objects released from commercially available spray products : temporal and spatial influences / J Expo Sci Env Epid 24(1):74~81 google schola Delmaar J / 2013 / First tier modeling of consumer dermal exposure to substances in consumer articles under REACH : A quantitative evaluation of the ECETOC TRA for consumers tool / Regul Toxicol Pharm 65(1):79~86 google schola ECETOC(European Centre for Ecotoxicology and Toxicology Chemicals) / 2014 / Targeted risk assessment user guide for the integrated tool TRAM version 3update to version 3.1 :1~34 google schola ECHA(European Chemicals Agency) / 2008 / Guidance on information requirements and chemical safety assessment – Part E: Risk characterization / European Chemicals Agency :1~75 google schola

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