지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 57 - 62 (6page)
이용수
초록· 키워드
오류제보하기
The nasal cavity encounters various irritants during inhalation such as dust and pathogens. To detect and remove these irritants, it has been postulated that the nasal mucosa epithelium has a specialized sensing system. The oral cavity,on the other hand, is known to have bitter taste receptors (T2Rs) that can detect harmful substances to prevent ingestion. Recently, solitary chemosensory cells expressing T2R subtypes have been found in the respiratory epithelium of rodents. In addition, T2Rs have been identified in the human airway epithelia. However, it is not clear which T2Rs are expressed in the human nasal mucosa epithelium and whether they mediate the removal of foreign materials through increased cilia movement. In our current study, we show that human T2R receptors indeed function also in the nasal mucosa epithelium. Our RT-PCR data indicate that the T2R subtypes (T2R3, T2R4, T2R5, T2R10, T2R13,T2R14, T2R39, T2R43, T2R44, T2R 45, T2R46, T2R47,T2R48, T2R49, and T2R50) are expressed in human nasal mucosa. Furthermore, we have found that T2R receptor activators such as bitter chemicals augments the ciliary beating frequency. Our results thus demonstrate that T2Rs are likely to function in the cleanup of inhaled dust and pathogens by increasing ciliary movement. This would suggest that T2Rs are feasible molecular targets for the development of novel treatment strategies for nasal infection and inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Braiman A / 2008 / Efficient mucociliary transport relies on efficient regulation of ciliary beating / Respir Physiol Neurobiol 163 : 202 ~ 207
Braun T / 2011 / Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: a pilot study / Rhinology 49 : 507 ~ 512
Chandrashekar J / 2006 / The receptors and cells for mammalian taste / Nature 444 : 288 ~ 294
Deshpande DA / 2010 / Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction / Nat Med 16 : 1299 ~ 1304
Finger TE / 2003 / Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration / Proc Natl Acad Sci USA 100 : 8981 ~ 8986
Braun T / 2011 / Solitary chemosensory cells in the respiratory and vomeronasal epithelium of the human nose: a pilot study / Rhinology 49 : 507 ~ 512
Chandrashekar J / 2006 / The receptors and cells for mammalian taste / Nature 444 : 288 ~ 294
Deshpande DA / 2010 / Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction / Nat Med 16 : 1299 ~ 1304
Finger TE / 2003 / Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration / Proc Natl Acad Sci USA 100 : 8981 ~ 8986
이 논문의 저자 정보
최근 본 자료
댓글(0)
0