지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 7 (7page)
이용수
초록· 키워드
오류제보하기
In this study, purified peptides from shrimp waste hydrolysates (SWHs) were examined for their inhibitory effects against β–secretase. During consecutive purification using a Sephadex G–25 column chromatography and high performance liquid chromatography on a C18 column, a potent β–secretase inhibitory peptide Asp–Val–Leu–Phe– His (629 Da) was isolated and identified from SWH24 by Q–TOF MS/MS and the IC50 value was determined to be 92.70 μM. The β–secretase inhibition patterns of the purified peptides were found to be competitive. Among synthesized β–secretase inhibitory peptides, Leu–Phe–His had higher β–secretase inhibitory activity than the others.
The result of this study suggests that the β–secretase inhibitory peptide derived from SWH24 could be potential candidates to develop nutraceuticals and pharmaceuticals.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bursavich MG / 2002 / Designing non–peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles / J Med Chem 45:541~558
Byun HG / 2005 / Chitooligosaccharides as a novel β– secretase inhibitor / Carbohyd Polym 61:198~202
Chen J / 1995 / Isolation and characterization of immunostimulative peptides from soybean / J Nutr Biochem 6:310~313
Cheung IWY / 2010 / Angiotensin–I–converting enzyme inhibitory activity and bitterness of enzymatically–produced hydrolysates of shrimp(Pandalopsis dispar)processing byproducts investigated by Taguchi design / Food Chem 122:1003~1012
Cheung LKY / 2012 / Effects of production factors and egg– bearing period on the antioxidant activity of enzymatic hydrolysates from shrimp (Pandalopsis dispar) processing byproducts / J Agric Food Chem 60:6823~6831
Byun HG / 2005 / Chitooligosaccharides as a novel β– secretase inhibitor / Carbohyd Polym 61:198~202
Chen J / 1995 / Isolation and characterization of immunostimulative peptides from soybean / J Nutr Biochem 6:310~313
Cheung IWY / 2010 / Angiotensin–I–converting enzyme inhibitory activity and bitterness of enzymatically–produced hydrolysates of shrimp(Pandalopsis dispar)processing byproducts investigated by Taguchi design / Food Chem 122:1003~1012
Cheung LKY / 2012 / Effects of production factors and egg– bearing period on the antioxidant activity of enzymatic hydrolysates from shrimp (Pandalopsis dispar) processing byproducts / J Agric Food Chem 60:6823~6831
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of β-secretase inhibitory peptide from fish skins in neuroblast cell
한국수산과학회 양식분과 학술대회
2016 .05
-
Effect of β-secretase inhibitory peptide from fish skins in neuroblast cell
한국수산과학회 양식분과 학술대회
2015 .10
-
Effect of β-Secretase Inhibitory Peptide from Fish Skins in Neuroblast Cell
한국식품영양과학회 학술대회발표집
2015 .08
-
β-secretase inhibitory activity of peptide purified from sailfin sandfish (Arctoscopus japonicus) protein hydrolysate
한국수산과학회 양식분과 학술대회
2018 .05
-
Purification of β−secretase Inhibitory Peptides from Sea Cucumber (Holothuria spinifera) Enzymatic Hydrolysates
한국수산과학회 양식분과 학술대회
2020 .07
-
A novel β-secretase inhibitory peptide from skate skin ameliorate memory and cognitive deficits in amyloid-beta mouse model of Alzheimer`s disease
한국수산과학회 양식분과 학술대회
2017 .05
-
Neuroprotective Effect of Biochanin A via the Inhibition of β-Secretase (BACE1)
한국식품영양과학회 학술대회발표집
2016 .10
-
Antioxidant and angiotensin-I converting enzyme inhibitory peptides from Hippocampus abdominalis
한국수산과학회 양식분과 학술대회
2021 .04
-
Effect of 42 amino acid long amyloid-β peptides on Arabidopsis plants
Journal of Plant Biotechnology
2020 .01
-
Purification and Idenfication of -secretase inhibitor from Brown Algae, Eisenia bicyclis Extract
한국수산과학회 양식분과 학술대회
2016 .10
-
박태기나무 씨 에탄올 추출물의 아세틸콜린에스테라제 억제 활성과 항아밀로이드 효과
한국약용작물학회지
2021 .10
-
Neuroprotective Effects of Hesperidin and its Aglycone Hesperetin as β-Secretase (BACE1) Inhibitors
한국식품영양과학회 학술대회발표집
2016 .10
-
Purification and Idenfication of β-secretase inhibitor from brown algae, Dictyota corlacea
한국수산과학회 양식분과 학술대회
2015 .10
-
Purification and Idenfication of β-secretase inhibitor from brown algae, Dictyota corlacea
한국수산과학회 양식분과 학술대회
2016 .05
-
Characterization of antioxidative peptide purified from black eelpout (Lycodes diapterus) hydrolysate
Fisheries and Aquatic Sciences
2019 .01
-
Computational insights into β-Secretase (BACE1) and Cholinesterases Inhibition by Zerumbone via Molecular Docking and ADMET Analysis
한국식품영양과학회 학술대회발표집
2019 .10
-
Biological activity of peptides purified from fish skin hydrolysates
Fisheries and Aquatic Sciences
2019 .01
-
Potential of Alkannin Derivatives Extracted from The Root of Arnebia euchroma for Effect of Inhibition Activity Against BACE1 (β-Secretase)
한국식품영양과학회 학술대회발표집
2020 .10
-
Neuroprotective effect of peptides from marine fish hydrolysates on amyloid beta peptide-induced toxicity in Neuron cells
한국수산과학회 양식분과 학술대회
2015 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0