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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 283 - 288 (6page)
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초록· 키워드
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Although the evolution of Arabidopsis thaliana and humans diverged approximately 1.6 billion years ago, recent studies have demonstrated that protein function and cellular processes involved in disease response remain remarkably conserved. Particularly, γ-secretase, a multisubunit protein complex that participates in intramembrane proteolysis (RIP) regulation, is also known to mediate the cleavage of more than 80 substrates including the amyloid precursor protein (APP) and the Notch receptor. Although the genes (PS1/2, APH-1, PEN-2, and NCT) coding for the γ-secretase complex components are present in plant genomes, their function remains largely uncharacterized . Given that the deposition of 42 amino acid long amyloid-β peptides (hAβ42) is thought to be one of the main causes of Alzheimer’s disease, we aimed to examine the physiological effects of hAβ42 peptides on plants. Interestingly, we found that Arabidopsis protoplast death increased after 24 h of exposure to 3 or 5 μM hAβ42 peptides. Furthermore, transgenic Arabidopsis plants overexpressing the hAβ42 gene exhibited changes in primary root length and silique phyllotaxy . Taken together, our results demonstrate that hA β42 peptides, a metazoan protein, significantly affect Arabidopsis protoplast viability and plant morphology.
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참고문헌 (29)
참고문헌 신청
Dahlgren KN / 2002 / Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability / J Biol Chem 277:32046~32053
Danon A / 2005 / Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana / Plant J 41:68~80
Grigorenko AP / 2002 / Novel class of polytopic proteins with domains associated with putative protease activity / Biochemistry (Mosc) 67:826~835
Haapasalo A / 2011 / The many substrates of presenilin/gamma-secretase / J Alzheimers Dis 25:3~28
Hays JB / 2002 / Arabidopsis thaliana, a versatile model system for study of eukaryotic genome-maintenance functions / DNA Repair (Amst) 1:579~600
Danon A / 2005 / Concurrent activation of cell death-regulating signaling pathways by singlet oxygen in Arabidopsis thaliana / Plant J 41:68~80
Grigorenko AP / 2002 / Novel class of polytopic proteins with domains associated with putative protease activity / Biochemistry (Mosc) 67:826~835
Haapasalo A / 2011 / The many substrates of presenilin/gamma-secretase / J Alzheimers Dis 25:3~28
Hays JB / 2002 / Arabidopsis thaliana, a versatile model system for study of eukaryotic genome-maintenance functions / DNA Repair (Amst) 1:579~600
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