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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 36 - 46 (11page)
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초록· 키워드
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Objective : In this study, the effect of Atractylodes japonica against LPS induced inflammation in mouse microglia BV2 cells was investigated.
Method : Microglia BV2 Cells viability was determined using the MTT assay. We used water, ethanol extract from Atractylodes japonica and studied on the anti-inflammatory effect of lipopolysaccharide-induced inflammation using reverse transcription polymerase chain reaction (RT-PCR), western blot, and nitric oxide detection on mouse microglia BV2 cells.
Result : The MTT assay revealed that it's extract has no significant cytotoxicity in the microglia BV2 cell. Various solvent extract from Atractylodes japonica inhibited nitrite production, iNOS protein and mRNA expression levels. And also it's extracts significantly reduced lipopolysaccharide-induced COX-2 activation in RT-PCR and western blot in lipopolysaccharide-induced microglia BV2 cells
Conclusion : In this study, it's extracts was shown to suppress NO production by inhibiting iNOS expression and COX-2 activity. With this effects of anti-inflammation, we suggests that, it's extracts may be a useful candidate for the development of a drug on the related inflammatory diseases in brain.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
/ / Regulation of biosynthesis of nitric oxide
/ 1987;417-32 / Annual Review of Medicine
/ 1991;111 / The effect of crude drugs using diuretic on horse kidney -ade (sine triphosphatase) : 138 ~ 45
/ 1995 / Dual inhibition oh nitric oxide and prostaglandin prodiction contributes to the antiinflammatory properties of nitric axide synthase inhibitor 96 : 301 ~ 308
/ 1995 / Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages 25 : 947 ~ 951
/ 1987;417-32 / Annual Review of Medicine
/ 1991;111 / The effect of crude drugs using diuretic on horse kidney -ade (sine triphosphatase) : 138 ~ 45
/ 1995 / Dual inhibition oh nitric oxide and prostaglandin prodiction contributes to the antiinflammatory properties of nitric axide synthase inhibitor 96 : 301 ~ 308
/ 1995 / Nitric oxide up-regulates the release of inflammatory mediators by mouse macrophages 25 : 947 ~ 951
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