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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 290 - 300 (11page)
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초록· 키워드
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Objectives: This study investigated the removal efficacy and cytotoxicity of a newly developed calcium hydroxide paste (cleaniCal, Maruchi) using N-2-methyl-pyrrolidone (NMP) as a vehicle in comparison with ApexCal (Ivoclar Vivadent) and Calcipex II (Nishika), which use different vehicles such as polyethylene glycol and propylene glycol, respectively.
Materials and Methods: Thirty maxillary premolars with oval-shaped canals were divided into 3 groups and the teeth were filled with one of the pastes. After removal of the paste, micro-computed tomographic (μ-CT) imaging was obtained to assess the volume of residual paste in the root canal of each tooth. The teeth were then split longitudinally and the area of the paste-coated surface was evaluated by stereomicroscopy. The cytotoxicity of each product was assessed using an agar overlay assay. The effect of each vehicle on cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The data were analyzed using one-way analysis of variance and Tukey's tests to detect any significance (p < 0.05).
Results: In the μ-CT and stereomicroscopic analysis, cleaniCal exhibited less remnants of medicament than ApexCal and Calcipex. cleaniCal showed a higher cytotoxicity than the other pastes in the agar overlay assay. Furthermore, NMP exhibited lower cell viability compared to the other vehicles.
Conclusions: cleaniCal showed better removal efficacy compared to the other products. However, clinicians should be aware of the higher cytotoxicity of the NMP-based material and consider its possible adverse effects on periradicular tissue when it is overfilled.
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참고문헌 (23)
참고문헌 신청
Aboudzadeh N / 2010 / Fabrication and characterization of poly(D,L-lactide-co-glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration / J Biomed Mater
Agrawal AG / 2015 / Toxicity Study of a Self-nanoemulsifying Drug Delivery System Containing N-methyl pyrrolidone / Drug Res (Stuttg) 65 : 446 ~ 448
Balvedi RP / 2010 / A comparison of two techniques for the removal of calcium hydroxide from root canals / Int Endod J 43 : 763 ~ 768
Bystrom A / 1985 / The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals / Endod Den
Calt S / 1999 / Dentinal tubule penetration of root canal sealers after root canal dressing with calcium hydroxide / J Endod 25 : 431 ~ 433
Agrawal AG / 2015 / Toxicity Study of a Self-nanoemulsifying Drug Delivery System Containing N-methyl pyrrolidone / Drug Res (Stuttg) 65 : 446 ~ 448
Balvedi RP / 2010 / A comparison of two techniques for the removal of calcium hydroxide from root canals / Int Endod J 43 : 763 ~ 768
Bystrom A / 1985 / The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals / Endod Den
Calt S / 1999 / Dentinal tubule penetration of root canal sealers after root canal dressing with calcium hydroxide / J Endod 25 : 431 ~ 433
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