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Objectives: Calcium hydroxide, a root canal temporary sealer, has long been used and it has anti-bacterial and anti-inflammatory activity. To investigate the properties of a newly developed calcium hydroxide paste comprising silicon-substituted hydroxyapatite (Si-HA), we examined the anti-inflammatory activity of the new calcium hydroxide paste in RAW 264.7 macrophages stimulated by lipopolysaccharide (LPS), which causes infection of the root canal. Methods: The test materials, including Calcipex II as control group and the newly developed TRC paste, were extracted from cell culture media and then diluted for experiment. In LPS-stimulated RAW 264.7 cells, the cytotoxicity and nitric oxide (NO) production of test materials were measured by MTT assay and Griess reagents, respectively. Also, the expression of the inducible nitric oxide synthase (iNOS) was assessed by western blotting. Results: The IC50 values of Calcipex II and TRC paste were 17.6 ㎎/㎖ and 13.5 ㎎/㎖, respectively. The level of NO, increased by LPS, was dose-dependently inhibited more by TRC paste than Calcipex II treatment. In addition, iNOS expression was decreased by 71% and 92% at concentrations of 2 ㎎/㎖ and 20 ㎎/㎖ of TRC paste, respectively. Conclusions: We demonstrated that the Si-HA calcium hydroxide paste has a slightly improved anti-inflammatory property and further studies are needed before clinical recommendations are proposed.
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참고문헌 (28)
참고문헌 신청
Bystrom A / 1985 / The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals / Endod Dent Traumatol 1:170~175
Athanassiadis B / 2007 / The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics / Aust Dent J 52:S64~S82
Narita H / 2010 / An explanation of the mineralization mechanism in osteoblasts induced by calcium hydroxide / Acta Biomater 6:586~590
Han B / 2013 / The biological performance of calcium hydroxide–loaded microcapsules / J Endod 39:1030~1034
Silva LAB / 2002 / Effect of calcium hydroxide on bacterial endotoxin in vivo / J Endod 28:94~98
Athanassiadis B / 2007 / The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics / Aust Dent J 52:S64~S82
Narita H / 2010 / An explanation of the mineralization mechanism in osteoblasts induced by calcium hydroxide / Acta Biomater 6:586~590
Han B / 2013 / The biological performance of calcium hydroxide–loaded microcapsules / J Endod 39:1030~1034
Silva LAB / 2002 / Effect of calcium hydroxide on bacterial endotoxin in vivo / J Endod 28:94~98
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