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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 291 - 297 (7page)
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Objectives: Due to various issues associated with materials currently used for artificial joint production, there is a growing need for the development of materials that can overcome these limitations and exhibit high biocompatibility. The objective of this study was to evaluate the biocompatibility of ultra-high molecular weight polyethylene (UHMWPE) as a material for 3-dimensional (3D)-printed artificial joint manufacturing.
Methods: UHMWPE was compared to commonly used metals, including Pure-Ti and Ti-6Al-4V, to assess its potential suitability for use in 3D-printed artificial joint. L-929 mouse fibroblast cells were cultured and exposed to UHMWPE, Pure-Ti, and Ti-6Al-4V discs. An agar overlay assay and MTT assay were conducted to assess cytotoxicity and cell viability. Zone index and lysis index were measured from culture dishes stained with neutral red, using a vernier caliper and microscope. Decolorization zones around the discs were measured to calculate zone index, and the lysis index was assessed to quantify cell death. Additionally, MTT assays were performed to measure cell viability compared to a control group. The cell response was determined by considering both the zone index and the lysis index.
Results: UHMWPE, Pure-Ti, and Ti-6Al-4V showed no significant cytotoxicity, with no decolorization zones or lysis observed in the agar overlay assay. The MTT assay also showed no statistically significant differences in the cell viability among the three discs.
Conclusion: Therefore, UHMWPE is a biocompatible material for 3D-printed artificial joint manufacturing, showing no significant cytotoxicity or reduction in cell viability.
Methods: UHMWPE was compared to commonly used metals, including Pure-Ti and Ti-6Al-4V, to assess its potential suitability for use in 3D-printed artificial joint. L-929 mouse fibroblast cells were cultured and exposed to UHMWPE, Pure-Ti, and Ti-6Al-4V discs. An agar overlay assay and MTT assay were conducted to assess cytotoxicity and cell viability. Zone index and lysis index were measured from culture dishes stained with neutral red, using a vernier caliper and microscope. Decolorization zones around the discs were measured to calculate zone index, and the lysis index was assessed to quantify cell death. Additionally, MTT assays were performed to measure cell viability compared to a control group. The cell response was determined by considering both the zone index and the lysis index.
Results: UHMWPE, Pure-Ti, and Ti-6Al-4V showed no significant cytotoxicity, with no decolorization zones or lysis observed in the agar overlay assay. The MTT assay also showed no statistically significant differences in the cell viability among the three discs.
Conclusion: Therefore, UHMWPE is a biocompatible material for 3D-printed artificial joint manufacturing, showing no significant cytotoxicity or reduction in cell viability.
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