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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 348 - 356 (9page)
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This study evaluated the dermal cytotoxicity of sodium bromate (NaBrO₃) and the protective effect of Aster tataricus L. (AT) extract against NaBrO₃-induced cytotoxicity in the cultured NIH3T3 fibroblasts. For this study, it was done the antioxidative effects such as electron donating (ED) activity and lipid peroxidation (LP) activity as well as cell viability. NaBrO₃ significantly decreased cell viability in a dose-dependent manner and its XTT<SUB>50</SUB> value was measured at a concentration of 54.4 μM in these cultures. The cytotoxicity of NaBrO₃ was determined as highly-toxic by Borenfreund and Puerner"s toxic criteria. The quercetin, antioxidant significantly increased cell viability against NaBrO₃-induced cytotoxicity. Regarding the protective effect of Aster tataricus (AT) L. extract on NaBrO₃-induced cytotoxicity, AT extract significantly increased the cell viability, the ED ability and the inhibitory ability of LP. From these findings, it suggested that the oxidative stress is involved in the cytotoxicity of NaBrO₃, and AT extract effectively protected NaBrO₃-induced cytotoxicity by antioxidative effects. Conclusively, the natural component like AT extract may be a putative therapeutic agent for the diminution or treatment of the cytotoxicity correlated with oxidative stress like hair dye component, NaBrO₃.
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REFERENCES
참고문헌 (33)
참고문헌 신청
Ahlbom GS / 2009 / Early alterations in protection and gene expression in rat kidney following bromate exposure / Food and Chemical Toxicology 47:1154~1160
A.O.A.C / 2005 / Official method of analysis / Association of official analytical chemists :21~21
Blois MS / 1958 / Antioxidant determination by the use of a stable free radical / Nature 181:1199~1200
Borenfreund E / 1985 / A simple quantitative procedure using monolayer culture for cytotoxicity assay (HTD/NR-90) / Journal of Tissue Culture Methods 9:7~9
천현자 / 2002 / Quercetin의 Melan-a 멜라닌세포의 멜라닌합성에 미치는 영향 / 생약학회지 33(3):245~251
A.O.A.C / 2005 / Official method of analysis / Association of official analytical chemists :21~21
Blois MS / 1958 / Antioxidant determination by the use of a stable free radical / Nature 181:1199~1200
Borenfreund E / 1985 / A simple quantitative procedure using monolayer culture for cytotoxicity assay (HTD/NR-90) / Journal of Tissue Culture Methods 9:7~9
천현자 / 2002 / Quercetin의 Melan-a 멜라닌세포의 멜라닌합성에 미치는 영향 / 생약학회지 33(3):245~251
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UCI(KEPA) : I410-ECN-0101-2020-510-000238572