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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제2호
- 발행연도
- 2016.1
- 수록면
- 177 - 183 (7page)
이용수
초록· 키워드
오류제보하기
Objective: This study compared the efficacy and tolerability of clonazepam with other benzodiazepines in patients with anxiety disorders.
Methods: Inclusion criteria were as follows: age ＞20 years, diagnosis of anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria, taking only one type of antidepressant, and prescribed one of three oral benzodiazepines (alprazolam, clonazepam, or lorazepam). At baseline and week 6, clinical benefit was evaluated using the Clinical Global Impression-Severity Scale (CGI-S), Clinical Global Impression-Anxiety Scale (CGI-anxiety), and Clinical Global Impression-Sleep Scale (CGI-sleep).
Results: Among 180 patients, no differences in demographic characteristics among the three benzodiazepine groups were noted.
After six weeks of treatment, all benzodiazepine groups showed significant improvements in CGI-S, CGI-anxiety, and CGI-sleep scores (p＜0.001). There were no differences in mean changes in CGI-S, CGI-anxiety and CGI-sleep among the three benzodiazepine groups. The incidence of side effects was significantly lower in the clonazepam group than with the other benzodiazepines.
The incidences of adverse events for the clonazepam, alprazolam, and lorazepam groups were 26.7% (n=20), 48.4% (n=31), and 43.9% (n=18), respectively.
Conclusion: The present study suggests that clonazepam is as efficacious as other benzodiazepines for the treatment of various anxiety disorders. Furthermore, the safety profile of clonazepam was superior to the other benzodiazepines in this study.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Wittchen HU / 2011 / The size and burden of mental disorders and other disorders of the brain in Europe 2010 / Eur Neuropsychopharmacol 21:655~679
Stahl SM / 2002 / Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder / J Clin Psychiatry 63:756~757
Cloos JM / 2009 / Current use of benzodiazepines in anxiety disorders / Curr Opin Psychiatry 22:90~95
Moroz G / 2004 / High-potency benzodiazepines: recent clinical results / J Clin Psychiatry 65(Suppl 5):13~18
Michael Kaplan E / 2005 / Benzodiazepines and anxiety disorders: a review for the practicing physician / Curr Med Res Opin 21:941~950
Stahl SM / 2002 / Don't ask, don't tell, but benzodiazepines are still the leading treatments for anxiety disorder / J Clin Psychiatry 63:756~757
Cloos JM / 2009 / Current use of benzodiazepines in anxiety disorders / Curr Opin Psychiatry 22:90~95
Moroz G / 2004 / High-potency benzodiazepines: recent clinical results / J Clin Psychiatry 65(Suppl 5):13~18
Michael Kaplan E / 2005 / Benzodiazepines and anxiety disorders: a review for the practicing physician / Curr Med Res Opin 21:941~950
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