지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 132 - 140 (9page)
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초록· 키워드
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Objectives: Very early-onset schizophrenia (VEOS) is a type of psychosis having a low frequency, insidious onset, and devastating clinical outcome. In this study, the demographic features, information on medication, clinical outcomes, and intellectual capability of patients diagnosed with VEOS in a hospital were analyzed to provide therapeutic strategies for this type of schizophrenia.
Methods: Using the electronic medical records of the National Center for Mental Health, 69 patients with VEOS were identified based on the DSM-5 criteria of schizophrenia. The data were summarized and analyzed according to the demographic characteristics, medications used, intellectual strength measured by the full intelligence quotient (FIQ) score, and current clinical status measured by the Clinical Global Impression-Severity (CGI-S) and various combinations of these parameters.
Results: The screened study group contained similar numbers of males and females. The younger the onset of psychosis, the lower the frequency. The study population included a significantly higher proportion of births in the winter season than that of the general population. The 3 most frequently used antipsychotic medications were risperidone and its derivatives, clozapine and olanzapine. Valproic acid and divalproex sodium were the most commonly added drugs for outcome augmentation. 53.5% of the study population had received benzodiazepines and/or hypnotics. The average FIQ of the study population was 69.4, which is quite low compared to previous Korean studies with similar populations. There was a weak negative correlation between FIQ and CGI-S, but it was not statistically significant. The average CGI-S score was 4.2, which meant that the patients were moderately ill.
Conclusion: This study demonstrated that patients with VEOS showed more frequent intellectual deficits at baseline and poorer outcomes than the control group. Risperidone, clozapine, valproic acid and their combinations were the most preferred medications for the treatment of psychosis. Benzodiazepines were quite commonly added for various reasons.
Methods: Using the electronic medical records of the National Center for Mental Health, 69 patients with VEOS were identified based on the DSM-5 criteria of schizophrenia. The data were summarized and analyzed according to the demographic characteristics, medications used, intellectual strength measured by the full intelligence quotient (FIQ) score, and current clinical status measured by the Clinical Global Impression-Severity (CGI-S) and various combinations of these parameters.
Results: The screened study group contained similar numbers of males and females. The younger the onset of psychosis, the lower the frequency. The study population included a significantly higher proportion of births in the winter season than that of the general population. The 3 most frequently used antipsychotic medications were risperidone and its derivatives, clozapine and olanzapine. Valproic acid and divalproex sodium were the most commonly added drugs for outcome augmentation. 53.5% of the study population had received benzodiazepines and/or hypnotics. The average FIQ of the study population was 69.4, which is quite low compared to previous Korean studies with similar populations. There was a weak negative correlation between FIQ and CGI-S, but it was not statistically significant. The average CGI-S score was 4.2, which meant that the patients were moderately ill.
Conclusion: This study demonstrated that patients with VEOS showed more frequent intellectual deficits at baseline and poorer outcomes than the control group. Risperidone, clozapine, valproic acid and their combinations were the most preferred medications for the treatment of psychosis. Benzodiazepines were quite commonly added for various reasons.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (44)
참고문헌 신청
[학술지(정기간행물)] - Madaan V / 2008 / Child and adolescent schizophrenia : pharmacological approaches / Expert Opin Pharmacother 9 : 2053 ~ 2068
[학술지(정기간행물)] - Rabinowitz J / 2006 / A population based elaboration of the role of age of onset on the course of schizophrenia / Schizophr Res 88 : 96 ~ 101
[학술지(정기간행물)] - Reichert A / 2008 / The psychopathological and psychosocial outcome of early-onset schizophrenia : preliminary data of a 13-year follow-up / Child Adolesc Psychiatry Ment Health 2 : 6 ~
[학술지(정기간행물)] - Díaz-Caneja CM / 2015 / Predictors of outcome in early-onset psychosis : a systematic review / NPJ Schizophr 1 : 14005 ~
[학술지(정기간행물)] - Clemmensen L / 2012 / A systematic review of the long-term outcome of early onset schizophrenia / BMC Psychiatry 12 : 150 ~
[학술지(정기간행물)] - Rabinowitz J / 2006 / A population based elaboration of the role of age of onset on the course of schizophrenia / Schizophr Res 88 : 96 ~ 101
[학술지(정기간행물)] - Reichert A / 2008 / The psychopathological and psychosocial outcome of early-onset schizophrenia : preliminary data of a 13-year follow-up / Child Adolesc Psychiatry Ment Health 2 : 6 ~
[학술지(정기간행물)] - Díaz-Caneja CM / 2015 / Predictors of outcome in early-onset psychosis : a systematic review / NPJ Schizophr 1 : 14005 ~
[학술지(정기간행물)] - Clemmensen L / 2012 / A systematic review of the long-term outcome of early onset schizophrenia / BMC Psychiatry 12 : 150 ~
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UCI(KEPA) : I410-ECN-0101-2017-516-002364610