지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제1호
- 발행연도
- 2018.1
- 수록면
- 57 - 61 (5page)
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초록· 키워드
오류제보하기
Objective: Risperidone long-acting injection (RLAI) was shown to be an alternative option in adult patients, but there is not available data in child and adolescents about this medication. The aim of this study is to evaluate the safety and efficiency profile of RLAI in a group of adolescents. Methods: Eleven cases with conduct disorder and severe aggressive behaviors were initiated treatment with risperidone oral form. All cases were then shifted to RLAI 25 mg injection in each 15 days due to poor compliance to oral risperidone treatment. Efficiency of treatment included indicators of clinical severity and improvement, which were evaluated by Clinical Global Impression-Severity (CGI-S) and Improvement (CGI-I). Safety evaluation was performed by using Extrapyramidal Symptoms Rating Scale, and by monitoring body weight. Follow-up visits were done at the treatment initiation, and 8th, 16th, and 24th weeks of first injection. Results: Study included 9 girls, and 2 boys, with a mean age of 14.9±1.0 years. The CGI-S scores decreased from 6.6±0.5 at the beginning to 2.2±1.1 at the last visit (p＜0.001), which is a very significant decrease through better clinical level. The CGI-I scores were also improved significantly from 2.4±0.5 to 1.9±0.5 at 24th week (p=0.001). Safety parameters were also showed favorable results, which there was no significant weight gain (p=0.076), and well-tolerated extrapyramidal adverse effects. Conclusion: Our results showed that RLAI is an efficient and safe medication option in the treatment of psychiatric disorders and severe behavioral problems in adolescents with low-compliance to oral treatment in our cases
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Lewis M / 1990 / Violation of expectancy, loss of control, and anger expressions in young infants / Dev Psychol 26:745~751
Alink LR / 2006 / The early childhood aggression curve: development of physical aggression in 10- to 50-month-old children / Child Dev 77:954~966
Tremblay RE / 2005 / Physical aggression during early childhood: trajectories and predictors / Can Child Adolesc Psychiatr Rev 14:3~9
Raine A / 2002 / Biosocial studies of antisocial and violent behavior in children and adults: a review / J Abnorm Child Psychol 30:311~326
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. / American Psychiatric Publishing
Alink LR / 2006 / The early childhood aggression curve: development of physical aggression in 10- to 50-month-old children / Child Dev 77:954~966
Tremblay RE / 2005 / Physical aggression during early childhood: trajectories and predictors / Can Child Adolesc Psychiatr Rev 14:3~9
Raine A / 2002 / Biosocial studies of antisocial and violent behavior in children and adults: a review / J Abnorm Child Psychol 30:311~326
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. / American Psychiatric Publishing
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