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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 218 - 223 (6page)
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초록· 키워드
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Background : This study was performed to investigate the prevalence of qnr genes in clinical isolates of Escherichia coli from Korea that produce extended-spectrum β-lactamases (ESBLs).
Methods : During the period of May to June 2005, we collected clinical isolates of E. coli that were intermediate or resistant to ceftazidime and/or cefotaxime from 11 Korean hospitals. Antimicrobial susceptibility was determined by the disk diffusion and agar dilution methods. ESBL production was confirmed phenotypically by the double-disk synergy test. ESBL and qnr genes were searched for by PCR amplification, and the PCR products were then subjected to direct sequencing.
Results : Double-disk synergy tests were positive in 84.3% (118/140) of ceftazidime- and/or cefotaxime-nonsusceptible E. coli isolates. The most prevalent types of ESBL in E. coli isolates were CTXM-14 (N=41) and CTX-M-15 (N=58). Other ESBLs were also identified, including CTX-M-3 (N=7),
CTX-M-9 (N=8), CTX-M-12 (N=1), CTX-M-57 (N=1), SHV-2a (N=2), SHV-12 (N=17) and TEM-52 (N=4). The qnrA1 and qnrB4 genes were identified in 4 and 7 ESBL-producing isolates, respectively.
Conclusions : CTX-M-type enzymes were the most common type of ESBL in E. coli isolates from Korea, and the qnr genes were not uncommon in ESBL-producing E. coli isolates. Dissemination of E. coli containing both ESBL and qnr genes could compromise the future usefulness of the expanded-
spectrum antibiotics for the treatment of infections.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bae IK / 2006 / Emergence of CTX-M-12 extended-spectrum beta-lactamase-producing Escherichia coli in Korea / J Antimicrob Chemother 58 : 1257 ~ 1259
Bush K / 2008 / Extended-spectrum beta-lactamases in North America, 1987-2006 / Clin Microbiol Infect 14 (S1) : S134 ~ S143
Clinical and Laboratory Standards Institute / 2008 / Performance standards for antimicrobial susceptibility testing. 18th Informational supplement. M100-S18 / Clinical and Laboratory St
Hooper DC / 1999 / Mechanisms of fluoroquinolone resistance / Drug Resist Updat 2 : 38 ~ 55
Hopkins KL / 2008 / Identification of novel plasmid-mediated extended-spectrum beta-lactamase CTX-M-57 in Salmonella enterica serovar Typhimurium / Int J Antimicrob Agents 3
Bush K / 2008 / Extended-spectrum beta-lactamases in North America, 1987-2006 / Clin Microbiol Infect 14 (S1) : S134 ~ S143
Clinical and Laboratory Standards Institute / 2008 / Performance standards for antimicrobial susceptibility testing. 18th Informational supplement. M100-S18 / Clinical and Laboratory St
Hooper DC / 1999 / Mechanisms of fluoroquinolone resistance / Drug Resist Updat 2 : 38 ~ 55
Hopkins KL / 2008 / Identification of novel plasmid-mediated extended-spectrum beta-lactamase CTX-M-57 in Salmonella enterica serovar Typhimurium / Int J Antimicrob Agents 3
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