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논문 기본 정보

자료유형
학술저널
저자정보
Hong Ki Min (Division of Rheumatology Department of Internal Medicine Konkuk University Medical Center) Jennifer Lee (Division of Rheumatology Department of Internal Medicine College of Medicine Seoul St. Mary's Hospi) Ji Hyeon Ju (Division of Rheumatology Department of Internal Medicine College of Medicine Seoul St. Mary's Hospi) Seung-Ki Kwok (Division of Rheumatology Department of Internal Medicine College of Medicine Seoul St. Mary's Hospi) Ho-Joong Youn (Division of Cardiology Department of Internal Medicine Seoul St. Mary's Hospital College of Medicin) 박성환 (가톨릭대학교)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제27권 제1호
발행연도
2020.1
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30 - 36 (7page)

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Axial spondyloarthritis (axSpA) is often accompanied by cardiac manifestations, such as valvular heart disease. In this prospective cohort study, we evaluated the incidence of cardiac abnormalities in Korean axSpA patients by echocardiography. Methods. AxSpA patients were prospectively recruited from a single tertiary hospital. Baseline demographic, clinical, radiographic, and echocardiographic data were collected at the time of enrollment. Echocardiography evaluations were performed with a focus on valvular heart disease and systolic and diastolic function. Logistic regression analyses were used to identify factors associated with diastolic dysfunction in axSpA. Results. A total of 357 axSpA patients were included in the analyses, of whom 78 (21.8%) exhibited diastolic dysfunction, with no reports of systolic dysfunction. Thirteen patients (3.6%) had valvular heart disease, and aortic valve regurgitation (n=5) and mitral valve regurgitation (n=6) were most common. Multivariable logistic regression analyses indicated that older age and higher body mass index (BMI) were positively associated with diastolic dysfunction, whereas human leukocyte antigen (HLA)-B27 positivity was negatively associated with diastolic dysfunction. Conclusion. Valvular heart disease is infrequent in Korean axSpA patients. However, diastolic dysfunction is common in axSpA patients, and is significantly associated with older age, higher BMI, and HLA-B27.

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