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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 415 - 419 (5page)
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초록· 키워드
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Background: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study was to identify fosfomycin resistance and characterize β-lactamase genes in fos-carrying isolates of Shigella flexneri from patients in China.
Methods: A total of 263 S. flexneri isolates were collected from 34 hospitals in the Anhui Province of China during September 2012-September 2015 and screened for fosA3, fosA, and fosC2 by PCR amplification and sequencing. The fos-carrying isolates were then screened for β-lactamase genes. The clonal relationships between fosA3-carrying isolates, the transmissibility of fosfomycin resistance, replicon types of plasmids carrying fosfomycin resistance genes and other associated resistance genes were investigated.
Results: Twenty-five of the 263 isolates (9.5%) showed resistance to fosfomycin, and 18 (6.8%) were positive for fosA3. None of the isolates was positive for fosA or fosC2. Seventeen of the isolates carrying fosA3 (94%) were CTX-M producers (seven CTX-M-55, five CTX-M-14, and five CTX-M-123), while three (16.7%) were TEM producers (TEM-1).Sixteen (88.9%) fosA3-carrying isolates exhibited multi-drug resistance. The replicon types of the 13 fosA3-carrying plasmids were IncF (n=13), IncHI2 (n=3), IncIl-Ir (n=2), and IncN (n=1).
Conclusions: Our results indicated that fosA3 could spread through plasmids in S. flexneri isolates, along with the blaCTX-M and blaTEM, which facilitate its quick dispersal. To the best of our knowledge, this is the first report of CTX-M-123-type ESBLs in S. flexneri isolates from patients in China.
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참고문헌 (22)
참고문헌 신청
Alrowais H / 2015 / Fosfomycin resistance in Escherichia coli, Pennsylvania, USA / Emerg Infe
Carattoli A / 2005 / Identification of plasmids by PCR-based replicon typing / J Microbiol Methods 63 : 219 ~ 228
Christopher PR / 2010 / Antibiotic therapy for Shigella dysentery / Cochrane Database Syst Rev : CD006784 ~
Falagas ME / 2008 / Fosfomycin: use beyond urinary tract and gastrointestinal infections / Clin Infect Dis 46 : 1069 ~ 1077
Falagas ME / 2010 / Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic revie
Carattoli A / 2005 / Identification of plasmids by PCR-based replicon typing / J Microbiol Methods 63 : 219 ~ 228
Christopher PR / 2010 / Antibiotic therapy for Shigella dysentery / Cochrane Database Syst Rev : CD006784 ~
Falagas ME / 2008 / Fosfomycin: use beyond urinary tract and gastrointestinal infections / Clin Infect Dis 46 : 1069 ~ 1077
Falagas ME / 2010 / Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic revie
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