지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 348 - 351 (4page)
이용수
초록· 키워드
오류제보하기
The genetic variant rs16754 of Wilms tumor gene 1 (WT1) has recently been described as an independent prognostic factor in AML patients. It is of great interest to test whether WT1 single nucleotide polymorphism can be used as a molecular marker in other types of cancer, to improve risk and treatment stratification. We performed sequencing analysis of exons 7 and 9 of WT1, which are known mutational hotspots, in a total of 73 patients with BCR-ABL1-negative myeloproliferative neoplasm (MPN) and 93 healthy controls. No previously reported WT1 mutations were identified in the present study. In Korean patients with BCR-ABL1-negative MPN, WT1 genetic variant rs16754 had no significant impact on clinical outcomes. We observed a significant difference in the allelic frequencies of WT1 rs16754 in Koreans between BCR-ABL1-negative MPN cases and healthy controls. Individuals carrying variant G alleles of WT1 rs16754 showed a relatively low prevalence of BCR-ABL1-negative MPN, compared with those carrying wild A alleles of WT1 rs16754 (Hazard ratio 0.10-0.65, P<0.05). Therefore, possession of the variant G allele of WT1 rs16754 may reduce the risk of developing BCR-ABL1-negative MPN.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Altshuler DM / 2010 / Integrating common and rare genetic variation in diverse human populations / Nature 467 : 52 ~ 58
Becker H / 2011 / Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cy
Choi Y / 2012 / Single nucleotide polymorphism of Wilms’ tumor 1 gene rs16754 in Korean patients with cytogenetically normal acute myeloid leukemia / Ann Hematol 91 : 671 ~
Damm F / 2010 / Single nucleotide polymorphism in the mutational hotspot of WT1predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia / J
Ho PA / 2011 / WT1synonymous single nucleotide polymorphism rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pedi
Becker H / 2011 / Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cy
Choi Y / 2012 / Single nucleotide polymorphism of Wilms’ tumor 1 gene rs16754 in Korean patients with cytogenetically normal acute myeloid leukemia / Ann Hematol 91 : 671 ~
Damm F / 2010 / Single nucleotide polymorphism in the mutational hotspot of WT1predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia / J
Ho PA / 2011 / WT1synonymous single nucleotide polymorphism rs16754 correlates with higher mRNA expression and predicts significantly improved outcome in favorable-risk pedi
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mutational Analysis of SH2B3 in Korean Patients With BCR-ABL1 Negative Myeloproliferative Neoplasm
Annals of Laboratory Medicine
2016 .01
-
Evaluation of a new flow cytometry based method for detection of BCR-ABL1 fusion protein in chronic myeloid leukemia
Blood Research
2017 .01
-
[Erratum]Two Cases of Acute Lymphoblastic Leukemia with an e1a3 BCR-ABL1 Fusion Transcript
Annals of Laboratory Medicine
2015 .01
-
Clinical significance of myeloproliferative neoplasms with JAK2V617F mutations and major BCR-ABL1 translocations: a literature review with case presentation
Blood Research
2020 .01
-
Chronic Myeloid Leukemia With Rare Variant b2a3 (e13a3) BCR-ABL1 Fusion
Annals of Laboratory Medicine
2016 .01
-
A case of e1a2 (minor, P190) BCR-ABL1-positive chronic myeloid leukemia in Korea
Blood Research
2021 .12
-
Straightforward Identification of Masked Polycythemia Vera Based on Proposed Revision of World Health Organization Diagnostic Criteria for BCR-ABL1-Negative Myeloproliferative Neoplasms
Annals of Laboratory Medicine
2015 .01
-
Genomic Profiling of Chronic Myelogenous Leukemia: Basic and Clinical Approach
대한암예방학회지
2017 .01
-
Two Cases of Acute Lymphoblastic Leukemia with an e1a3 BCR-ABL1 Fusion Transcript
Annals of Laboratory Medicine
2015 .01
-
Performance Evaluation of the QXDx BCR-ABL %IS Droplet Digital PCR Assay
Annals of Laboratory Medicine
2020 .01
-
Detection of NUP214-ABL1 translocation using BCR-ABL1 dual color FISH probes in T-cell acute lymphoblastic leukemia–an illustrative report and review of literature
Blood Research
2022 .12
-
GATA1 Expression in BCR/ABL1-negative Myeloproliferative Neoplasms
Annals of Laboratory Medicine
2018 .01
-
Impact of timely BCR-ABL1 monitoring before allogeneic stem cell transplantation among patients with BCR-ABL1-positive B-acute lymphoblastic leukemia
Blood Research
2021 .09
-
골수증식 종양의 2017년 WHO 진단기준 주요 변경 사항의 이해
대한내과학회지
2018 .01
-
A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement
Annals of Laboratory Medicine
2017 .01
-
Comparison of biochemical recurrence in prostate cancer patients treated with radical prostatectomy or radiotherapy
Investigative and Clinical Urology
2015 .01
-
A look inside the body of a BCR-ABL1?like acute lymphoblastic leukemia patient: the first case report highlighting the continued relevance of autopsy practice
Blood Research
2021 .12
-
JAK2 V617F-Positive Acute Myeloid Leukemia: Clinicopathological Features of Two Cases
Laboratory Medicine Online
2022 .01
-
Promyelocytic Blast Phase of Chronic Myeloid Leukemia, BCR-ABL1 -Positive: Points to be Considered at Diagnosis
Annals of Laboratory Medicine
2021 .01
-
Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0