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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 296 - 305 (10page)
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Background: This study aimed to determine GATA1 expression levels to better characterize subgroups in BCR/ABL1-negative myeloproliferative neoplasms (MPNs). Methods: This study enrolled 49 patients diagnosed as having BCR/ABL1-negative MPN on the basis of the 2016 World Health Organization classification : nine polycythemia vera (PV), 17 essential thrombocythemia (ET), 12 prefibrotic primary myelofibrosis (prePMF), and 11 overt primary myelofibrosis (PMF). Relevant clinical and laboratory data were retrieved from the medical records. The molecular analysis of CALR and MPL mutations and quantification of JAK2 V617F allele burden were performed. GATA1 expression was assessed by an immunohistochemical assay on bone marrow biopsy. GATA1 expression was analyzed serially in 18 patients. Results: GATA1 expression decreased significantly in PMF compared with that in other subtypes, while no statistical difference was identified between ET and prePMF. GATA1 expression did not differ according to the mutation profiles or the allele burden of JAK2 V617F, but it decreased significantly in patients with overt fibrosis or leukemic transformation. Conclusions: Our results suggest that GATA1 expression is significantly low in PMF and decreases with progressive fibrosis and possibly with leukemic transformation, although our attempt to accurately distinguish between subgroups using GATA1 immunohistochemical approach did not achieve statistical significance. A large patient cohort with long term follow-up is required to evaluate the prognostic value of GATA1 expression.
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참고문헌 (40)
참고문헌 신청
Arber DA / 2016 / The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia / Blood 127:2391~2405
Levine RL / 2013 / Another piece of the myeloproliferative neoplasms puzzle / N Engl J Med 369:2451~2452
Vannucchi AM / 2009 / Advances in understanding and management of myeloproliferative neoplasms / CA Cancer J Clin 59:171~191
Cervantes F / 2008 / Life expectancy and prognostic factors in the classic BCR/ABL-negative myeloproliferative disorders / Leukemia 22:905~914
Tefferi A / 2007 / Validation and comparison of contemporary prognostic models in primary myelofibrosis: analysis based on 334 patients from a single institution / Cancer 109:2083~2088
Levine RL / 2013 / Another piece of the myeloproliferative neoplasms puzzle / N Engl J Med 369:2451~2452
Vannucchi AM / 2009 / Advances in understanding and management of myeloproliferative neoplasms / CA Cancer J Clin 59:171~191
Cervantes F / 2008 / Life expectancy and prognostic factors in the classic BCR/ABL-negative myeloproliferative disorders / Leukemia 22:905~914
Tefferi A / 2007 / Validation and comparison of contemporary prognostic models in primary myelofibrosis: analysis based on 334 patients from a single institution / Cancer 109:2083~2088
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