지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Malondialdehyde (MDA), a lipid peroxidation by-product, has been widely used as an indicator of oxidative stress. Urinary 2-naphthol, a urinary PAH metabolite, is used as a marker of ambient particulate exposure and is associated with lung cancer and chronic obstructive pulmonary disease. However, the stability and intra-individual variation associated with urinary MDA and 2-naphthol have not been thoroughly addressed. The objective of this study was to assess the stability and intraindividual variation associated with urinary MDA and 2- naphthol.
Methods : Urine samples were collected from 10 healthy volunteers (mean age 34, range 27~42 years old). Each sample was divided into three aliquots and stored under three different conditions. The levels of urinary MDA and 2- naphthol were analyzed 1) just after sampling, 2) after storage at room temperature (21!) for 16 hours, and 3) after storage in a -20! freezer for 16 hours. In addition, an epidemiological study was conducted in 44 Chinese subjects over a period of 3 weeks. The urinary MDA and 2- naphthol were measured by HPLC three times.
Results : There was no difference in the levels of urinary MDA and 2-naphthol between the triplicate measurements (n=10, p=0.84 and p=0.83, respectively). The intra-class correlation coefficients (ICC) for urinary MDA and 2- naphthol were 0.74 and 0.42, respectively. However, the levels of PM2.5 in the air were well correlated with the levels of both MDA and 2-naphthol in the epidemiological study.
Conclusions : These results suggest that urinary MDA and 2-naphthol remain stable under variable storage conditions, even at room temperature for 16 hours, and indicate that these markers can be used in epidemiological studies involving various sample storage conditions. The intra-CC of urinary 2-naphthol and MDA were acceptable for application to epidemiological studies.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Armstrong, B.K. / 1994 / Principles of Exposure Measurement in Epidemiology / Oxford University Press
Gika, H.G. / 2007 / Within-day reproducibility of an HPLC-MS-Based method for metabonomic analysis: Application to human urine / J Proteome Res 6(8):3291~3303
Feldmann, J. / 1999 / Sample preparation and storage can change arsenic speciation in human urine / Clin Chem 45(11):1998~1997
Dunn, W.B. / 2008 / A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols / Int J Epidemiol 37(1):23~30
Wu, T. / 2004 / Stability of measurements of biomarkers of oxidative stress in blood over 36 hours / Cancer Epidemiol Biomarkers Prev 13(8):1399~1402
Gika, H.G. / 2007 / Within-day reproducibility of an HPLC-MS-Based method for metabonomic analysis: Application to human urine / J Proteome Res 6(8):3291~3303
Feldmann, J. / 1999 / Sample preparation and storage can change arsenic speciation in human urine / Clin Chem 45(11):1998~1997
Dunn, W.B. / 2008 / A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols / Int J Epidemiol 37(1):23~30
Wu, T. / 2004 / Stability of measurements of biomarkers of oxidative stress in blood over 36 hours / Cancer Epidemiol Biomarkers Prev 13(8):1399~1402
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