일개 농촌지역의 초등학생과 주민에서 다환성 방향족 탄화수소와 톨루엔 노출이 요중 Thiobarbituric Acid Reactive Substance 농도에 미치는 영향

김대선; 이철호; 엄상용; 강택신; 김용대; 김헌

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자료유형: 학술저널

저자정보: 김대선 이철호 엄상용 강택신 김용대 김헌

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제1호

발행연도: 2008.1

수록면: 61 - 67 (7page)

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Objectives : Polycyclic aromatic hydrocarbons (PAH) and toluene have been reported to induce reactive oxygen species and oxidative stress. This study was performed to investigate the effects of low level exposure to PAHs or toluene on the lipid peroxidation level in elementary school children and the elderly in a rural area. Methods : Forty seven elementary school children and 40 elderly people who were living in a rural area and not occupationally exposed to PAH or toluene were the subjects of this study. Information about active or passive smoking and diet was obtained using a self-administered questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2- naphthol, hippuric acid and thiobarbituric acid reactive substance (TBARS) concentrations were measured, and these values were corrected with the urinary creatinine concentration. Results : In school children, the geometric means of the urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels were 0.02 Gmol/mol creatinine, 0.47 Gmol/mol creatinine, 0.14 g/g creatinine and 0.95 Gmol/g creatinine, respectively. Those values for the elderly were 0.07 Gmol/mol creatinine, 1.87 Gmol/mol creatinine, 0.11 g/g creatinine and 1.18 G mol/g creatinine, respectively. The mean levels of urinary 1- OHP, 2-naphthol and TBARS were significantly higher in the elderly subjects than in the children. The urinary TBARS level was not correlated with the urinary 1-OHP, 2- naphthol and hippuric acid, but they were correlated with the age of the subjects. Conclusions : These results suggest that low level inhalation exposure to PAH or toluene does not markedly increase lipid peroxidation, and age is a significant determinant of lipid peroxidation.

#Polycyclic aromatic hydrocarbon #PAH) #1-Hydroxypyrene #1-OHP) #2-Naphthol #Hippuric acid #Thiobarbituric acid reactive substance #TBARS).

참고문헌 (24)

참고문헌 신청

Baselt, R.C. / 1980 / Plasma and urine concentrations of methapyrilene by nitrogenphosphorus gas-liquid chromatography / J Chromatogr 183 (2) : 234 ~ 238

Becher, G. / 1983 / Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine / Cancer Lett 17 (3) : 301 ~ 311

Chen, H.J. / 2005 / Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct

Clayton, G.D. / 1981 / PattyOs Industrial Hygiene and Toxicology / John Wiley & Sons : 3283 ~ 3291

Ding, A.H. / 1984 / Singlet oxygen in coppercatalyzed lipid peroxidation in erythrocyte membranes / Lipids 19 (4) : 278 ~ 284

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