비알코올성 지방간과 대사증후군 및 혈청 카로테노이드와의 관련성

박선균; 이현정; 이덕희; 이성국; 천병렬; 김성애; 이혜성; 손효경; 김성희

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자료유형: 학술저널

저자정보: 박선균 이현정 이덕희 이성국 천병렬 김성애 이혜성 손효경 김성희

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제1호

발행연도: 2008.1

수록면: 39 - 44 (6page)

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Objectives : This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. Methods : This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). Results : After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum S- carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum T-carotene, lycopene, S-cryptoxanthin and lutein were not decreased. Conclusions : This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum S-carotene level.

#Fatty liver #Metabolic syndrome X #Insulin resistance #Carotenoids #Obesity #Oxidative stress

참고문헌 (24)

참고문헌 신청

Ahn J.E. / 1991 / A cross-sectional study on prevalence rate and contributing factors of fatty liver diagnosed by ultrasonography / J Prev Med Public Health 24 (2) : 195 ~ 2

Bahcecioglu I.H. / 2005 / Levels of serum vitamin A, alpha-tocopherol and malondialdehyde in patients with non-alcoholic steatohepatitis: Relationship with histopathologic s

Bieri J.G. / 1979 / Simultaneous determination of T-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography / Am J Clin Nutr 32 (10) : 2143 ~ 21

Chae H.B. / 2000 / Nonalcoholic fatty liver disease : A spectrum of clinical and sonographical severity / Chungbuk Med J 10 (1) : 43 ~ 51

Chalasani N. / 2004 / Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis / Am J Gastroenterol 99 (8

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