일부 종합검진 수검자 중 비알코올성 지방간과 심혈관질환 위험요인과의 관련성

유재희; 이강숙; 이선영; 홍아름; 박용상

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자료유형: 학술저널

저자정보: 유재희 이강숙 이선영 홍아름 박용상

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제6호

발행연도: 2008.1

수록면: 407 - 412 (6page)

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Objectives : The purpose of this study was to evaluate the relationship of nonalcoholic fatty liver and cardiovascular risk factors. Methods : This study was conducted to investigate the association of nonalcoholic fatty liver and cardiovascular risk factors for adult men (n=2976) and women (n=2442) who were over 19 years old, after excluding the HBsAg(+) or anti-HCV(+) patients and the men and women with increased alcohol intake (men: 40 g/week, women: 20 g/week). Results : Compared with the normal liver subjects, the nonalcoholic fatty liver subjects showed a significantly increased frequency of abnormal systolic blood pressure ( 120 mmHg), fasting blood sugar ( 100 mg/dL), total cholesterol ( 200 mg/dL), triglyceride ( 150 mg/dL), high density lipoprotein cholesterol (<40 mg/dL), low density lipoprotein cholesterol ( 130g m/dL) and abdominal obesity in men, and all these measures were significantly increased in the women except for abnormal HDL cholesterol. After adjusting for the body mass index, age, smoking, exercise and a nonalcoholic liver, the odds ratios of an abnormal waist hip ratio were 1.35(95% Confidence Interval=1.05-4.72) in the mild fatty liver, 1.61(1.19-2.18) in the moderate fatty liver, 2.77(1.57-4.92) in the severe fatty liver compared with a normal liver. The adjusted odds ratios for abnormal fasting blood sugar were 1.26(1.03-1.53) in the mild fatty liver, 1.62(1.27-2.06) in the moderate fatty lliver and 1.77(1.12-2.78) in the severe fatty liver. The adjusted odds ratios for abnormal triglyceride were 1.38(1.11-1.72) in the mild fatty liver, 1.73(0.33-2.24) in the moderate fatty liver and 1.91(1.17-3.10) in the severe fatty liver of men. Adjusted odds ratios for abnormal triglyceride were 1.50(1.04-2.15) in mild, 1.71(1.07-2.68) in moderate, 1.81(0.69-4.38) in severe fatty liver of women. Conclusions : The nonalcoholic fatty liver subjects had more cardiovascular risk factors compared with the normal liver subjects. Thus, prevention and treatment of the nonalcoholic fatty liver is necessary by lifestyle modifications such as restriction of alcohol intake, no smoking, exercise and adequate eating habits.

Objectives : The purpose of this study was to evaluate the relationship of nonalcoholic fatty liver and cardiovascular risk factors. Methods : This study was conducted to investigate the association of nonalcoholic fatty liver and cardiovascular risk factors for adult men (n=2976) and women (n=2442) who were over 19 years old, after excluding the HBsAg(+) or anti-HCV(+) patients and the men and women with increased alcohol intake (men: 40 g/week, women: 20 g/week). Results : Compared with the normal liver subjects, the nonalcoholic fatty liver subjects showed a significantly increased frequency of abnormal systolic blood pressure ( 120 mmHg), fasting blood sugar ( 100 mg/dL), total cholesterol ( 200 mg/dL), triglyceride ( 150 mg/dL), high density lipoprotein cholesterol (<40 mg/dL), low density lipoprotein cholesterol ( 130g m/dL) and abdominal obesity in men, and all these measures were significantly increased in the women except for abnormal HDL cholesterol. After adjusting for the body mass index, age, smoking, exercise and a nonalcoholic liver, the odds ratios of an abnormal waist hip ratio were 1.35(95% Confidence Interval=1.05-4.72) in the mild fatty liver, 1.61(1.19-2.18) in the moderate fatty liver, 2.77(1.57-4.92) in the severe fatty liver compared with a normal liver. The adjusted odds ratios for abnormal fasting blood sugar were 1.26(1.03-1.53) in the mild fatty liver, 1.62(1.27-2.06) in the moderate fatty lliver and 1.77(1.12-2.78) in the severe fatty liver. The adjusted odds ratios for abnormal triglyceride were 1.38(1.11-1.72) in the mild fatty liver, 1.73(0.33-2.24) in the moderate fatty liver and 1.91(1.17-3.10) in the severe fatty liver of men. Adjusted odds ratios for abnormal triglyceride were 1.50(1.04-2.15) in mild, 1.71(1.07-2.68) in moderate, 1.81(0.69-4.38) in severe fatty liver of women. Conclusions : The nonalcoholic fatty liver subjects had more cardiovascular risk factors compared with the normal liver subjects. Thus, prevention and treatment of the nonalcoholic fatty liver is necessary by lifestyle modifications such as restriction of alcohol intake, no smoking, exercise and adequate eating habits.

#Nonalcoholic fatty liver #Cardiovascular risk factors

참고문헌 (28)

참고문헌 신청

Akahoshi M / 2001 / Corr

Anderson AJ / 1988 / Body fat distribution, plasma lipids, and lipoproteins / Arteriosclerosis 8 (1) : 88 ~ 94

Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med 346 (16) : 1221 ~ 1231

Chobanian AV / 2003 / Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure / Hypertension 42 (6) : 1206

Clark JM / 2002 / Nonal coholic fatty liver disease / Gastroenterology 122 (6) : 1649 ~ 1657

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