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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 30 - 34 (5page)
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초록· 키워드
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Purpose: A combination of paclitaxel and cisplatin is
an effective and safe regimen for advanced non-small cell
lung cancer (NSCLC). We conducted a multi-center,
phase II trial to evaluate the efficacy and safety of
Genexol (paclitaxel) and cisplatin in patients with
NSCLC.
Materials and Methods: Chemotherapy-naïve patients
having histologically confirmed NSCLC were enrolled.
Genexol was administered at 175 mg/m2 as a 3-hour
intravenous infusion and cisplatin at 75 mg/m2 as an
intravenous infusion on day 1 every 3 weeks.
Results: Twenty-five of 27 patients that were entered
from 5 hospitals between Jan 2001 and Aug 2001 received
chemotherapy. On an intent-to-treat basis, 9 patients
(36%) achieved a partial response, 7 patients (28%) a
stable disease, and 5 patients (20%) progressed. The
overall response rate was 36% (95% CI, 17 to 55%). The
median duration of the response was 7.8 months (95%
CI, 6.6 to 9.0 months). The median time to progression
was 7.4 months (95% CI, 5.3 to 9.5 months), and median
overall survival was 13.3 months (95% CI, 10.8 to 15.9
months) for the intent-to-treat population. The major toxicity
was hematological, with grade 3 and 4 neutropenia
in 10% (10/106) of the total cycles. The non-hematologic
toxicity was mild, and grade 3 emesis was observed in
2 patients (8%). One patient experienced a moderate
degree hypersensitivity reaction.
Conclusion: The results suggest that a combination of
Genexol and cisplatin is an effective and well-tolerated
regimen for patients with NSCLC. (Cancer Res Treat. 2003;35:30-34)
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