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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 106 - 110 (5page)
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Purpose: We wanted to assess the effectiveness and safety of combination chemotherapy with paclitaxel, 5-fluorouracil (5-FU) and cisplatin for treating advanced gastric cancer.
Materials and Methods: Patients with metastatic or recurrent gastric cancer were entered into this study. Paclitaxel at a dose of 135 mg/m² on day 1, 5-FU 1 g/m²/ day in a 24 hour continuous infusion from day 1 to day 4 and cisplatin 60 mg/m² on day 1 were administered. This regimen was repeated every 3 weeks.
Results: A total of 34 patients were enrolled in this study. Among them, 33 patients were finally evaluable for their response. 17 (51.5%) patients had a partial response (95% CI: 26.0∼77.0%). The median duration of overall survival was 13.2 months. Grade 3 or 4 neutropenia and thrombocytopenia were observed in 15.2% and 1.1% of all the cycles, respectively. Grade 3 stomatitis and neurotoxicity were observed in 20.6% and 1.1% of all patients, respectively. Grade 4 non-hematologic toxicity was not observed.
Conclusions: The regimen of paclitaxel, 5-FU and cisplatin demonstrated activity and accepatable toxicity for treating metastatic gastric cancer.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ajani JA / 1998 / Phase II study of taxol in patients with advanced gastric carcinoma / Cancer J Sci Am 4 : 269 ~ 74
Ajani JA / 2007 / Quality of life with docetaxel plus cisplatin and fluorouracil compared with cisplatin and fluorouracil from a phase III trial for advanced gastric or gast
Brennan MF / 2005 / Current status of surgery for gastric cancer: a review / Gastric Cancer 8 : 64 ~ 70
Cascinu S. / 1998 / Phase II study of paclitaxel in pretreated advanced gastric cancer / Anticancer Drugs 9 : 307 ~ 10
Edwards BK / 2005 / Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment / J Natl Cancer Inst 97 : 1407 ~ 27
Ajani JA / 2007 / Quality of life with docetaxel plus cisplatin and fluorouracil compared with cisplatin and fluorouracil from a phase III trial for advanced gastric or gast
Brennan MF / 2005 / Current status of surgery for gastric cancer: a review / Gastric Cancer 8 : 64 ~ 70
Cascinu S. / 1998 / Phase II study of paclitaxel in pretreated advanced gastric cancer / Anticancer Drugs 9 : 307 ~ 10
Edwards BK / 2005 / Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment / J Natl Cancer Inst 97 : 1407 ~ 27
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A Phase II Study on Continuous Infusional Paclitaxel and 5-Fu as First-line Chemotherapy for Patients with Advanced Esophageal Cancer
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A Multi-Center, Phase II Clinical Trial of Genexol (Paclitaxel) and Cisplatin for Patients with Non-SmallCell Lung Cancer
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A Phase II Study of Oxaliplatin Combined with 5-Fluorouracil and Leucovorin (Mayo Clinic Regimen) in 5-FluorouracilRefractory Colorectal Cancer
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