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논문 기본 정보

자료유형
학술저널
저자정보
Lilian Yan Liang (Institute of Digestive Disease The Chinese University of Hong Kong) Hye Won Lee (Department of Internal Medicine Yonsei University College of Medicine) Vincent Wai-Sun Wong (Department of Medicine and Therapeutics The Chinese University of Hong Kong) Terry Cheuk-Fung Yip (Medical Data Analytics Centre The Chinese University of Hong Kong) Yee-Kit Tse (Institute of Digestive Disease The Chinese University of Hong Kong) Vicki Wing-Ki Hui (Institute of Digestive Disease The Chinese University of Hong Kong) Grace Chung-Yan Lui (Department of Medicine and Therapeutics The Chinese University of Hong Kong) Henry Lik-Yuen Chan (Institute of Digestive Disease The Chinese University of Hong Kong) Grace Lai-Hung Wong (Institute of Digestive Disease The Chinese University of Hong Kong)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제27권 제3호
발행연도
2021.1
수록면
499 - 509 (11page)

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Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score based on serum fibrosis scores to predict HCC in treatment-naive chronic hepatitis B (CHB) patients. Methods: Fifteen thousand one hundred eighty-seven treatment-naive adult CHB patients were identified to form the training cohort in this retrospective study. Individual fibrosis score was included to construct a new HCC prediction score. The score was externally validated in an independent treatment-naive Korean CHB cohort. Results: 180/15,187 patients (1.2%) in training cohort and 47/4,286 patients (1.1%) in validation cohort developed HCC during a mean follow-up of 52 and 50 months, respectively. The newly developed HCC risk score, Liang score, is composed of gender, age, hepatitis B virus DNA, fibrosis-4 (FIB-4) index, and ranges from 0 to 22. Area under the timedependent receiver operating characteristic curve of Liang score was 0.79 (95% confidence interval, 0.70?0.89). A cutoff value of nine provided an extremely high negative predictive value of 99.9% and high sensitivity of 90.0% at 5 years in the validation cohort. Patients with Liang score ≤9 had HCC incidence <0.2% per year in both training and validation cohorts, in whom HCC surveillance might be exempted. Conclusion: A novel HCC risk score, Liang score, based on FIB-4 index, is applicable and accurate to identify treatmentnaive CHB patients with very low risk of HCC to be exempted from HCC surveillance.
#Hepatitis B #Chronic #Carcinoma #Hepatocellular #Fibrosis #Surveillance

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참고문헌 (35)

참고문헌 신청
Polaris Observatory Collaborators / 2018 / Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016 : a modelling study / Lancet Gastroenterol Hepatol 3:383~403 google schola Singal AG / 2020 / Epidemiology and surveillance for hepatocellular carcinoma : new trends / J Hepatol 72:250~261 google schola Wong GL / 2008 / Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis / Liver Int 28:79~87 google schola Terrault NA / 2018 / Update on prevention, diagnosis, and treatment of chronic hepatitis B : AASLD 2018 hepatitis B guidance / Hepatology 67:1560~1599 google schola European Association for the Study of the Liver / 2017 / EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection / J Hepatol 67:370~398 google schola

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