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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.2
- 수록면
- 79 - 85 (7page)
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초록· 키워드
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Head and neck squamous cell carcinoma (HNSCC) include epithelial tumors arising in thestructures of aerodigestive tract such as oral and nasal cavity, pharynx, larynx, paranasal sinuses,and local lymph nodes. HNSCC is the sixth most common cancer worldwide, and itsprognosis is very poor. MicroRNAs (miRNAs) are small single stranded noncoding RNAswhich are about 19-25 nucleotides involved in cell proliferation, development, differentiationand metastasis. It is believed that miRNA alterations correlate with initiation and progressionof cancer cell proliferation or inhibition of tumorigenesis especially in development, progression,and metastasis of HNSCC. Altered expression of miRNAs could be novel molecular biomarkersfor the diagnosis and prognosis of HNSCC. Despite the advances in cancer treatment,the mortality rate of HNSCC is still high. The potential application of miRNAs for cancertherapy has been demonstrated in many studies. In this review, we discuss the very recentstudies on different aspects of miRNA dysregulation with their clinical significance and miRNA-based therapy.
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