The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis

Abozar Soleimani; Yousef Rahmani; Negin Farshchian; Ali Delpisheh; Kivan Khassi; Afshar Shahmohammadi; Nasrin Amirifard

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저자정보: Abozar Soleimani (Department of Epidemiology Ilam University of Medical Sciences) Yousef Rahmani (Imam Ali and Taleghani Hospital Kermanshah University of Medical Sciences) Negin Farshchian (Imam Reza Hospital Kermanshah University of Medical Sciences) Ali Delpisheh (Ilam University of Medical Sciences) Kivan Khassi (Province Health Center Kermanshah University of Medical Sciences) Afshar Shahmohammadi (Imam Ali and Taleghani Hospital Kermans) Nasrin Amirifard (Imam Reza Hospital Kermanshah University of Medical Sciences)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제21권 제4호

발행연도: 2016.1

수록면: 288 - 293 (6page)

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Background: Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes. p53 gene plays an important role in conserving and sustaining the genome as a tumor suppressing gene. Change and polymorphism at codon 72 of p53 gene are correlated with increased risk of lung, mouth, endometrial, prostate, and colorectal cancers, and could be considered an indicator of susceptibility to breast cancer. Methods: Twelve studies (1,190 cases and 1,145 control studies with evaluation of three types of Arg/Arg, Arg/Pro, and Pro/Pro genotypes) have been conducted using keywords, such as polymorphism at codon 72, gene p53 polymorphisms, and the relation between polymorphisms and breast cancer, from databases in Iran, including Magiran, Medlibe, Sid, and Iranmedex, as well as Latin databases such as PubMed, Google Scholar, Science Direct, and Scopus. Results: The OR for Arg/Arg is 1.58 (95% CI: 2.45 to 1.01), the OR for Arg/Pro is 0.75 (95% CI: 1.10 to 0.51), and the OR for Pro/Pro is 0.62 (95% CI: 0.93 to 0.42). p53 gene polymorphism at codon 72 is statistically significant in Arg/Arg and Pro/Pro genotypes. Conclusions: Arg/Arg genotype can be considered as a risk factor for breast cancer, and Pro/Pro genotype can be accounted for as a protective factor against breast cancer.

참고문헌 (34)

참고문헌 신청

Vogel VG / 2000 / Breast cancer prevention: a review of current evidence / CA Cancer J Clin 50:156~170

Chu KC / 1996 / Recent trends in U.S. breast cancer incidence, survival, and mortality rates / J Natl Cancer Inst 88:1571~1579

Ghafoor A / 2003 / Trends in breast cancer by race and ethnicity / CA Cancer J Clin 53:342~355

World Health Organization / 2015 / Fact sheet No297 / WHO

Etemadi K / 2012 / National Report on Cancer Registration in 2009 year :16

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