지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 831 - 839 (9page)
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Purpose: To examine the usefulness of various receptor tyrosine kinase expressions as prognostic markers and therapeutic targetsin muscle invasive urothelial cancer (UC) patients.
Materials and Methods: We retrospectively analyzed the data of 98 patients with muscle invasive UC who underwent radical cystectomybetween 2005 and 2010 in Yonsei Cancer Center. Using formalin fixed paraffin embedded tissues of primary tumors, immunohistochemicalstaining was done for human epidermal growth factor receptor 2 (HER2), fibroblast growth factor receptor 1 (FGFR1), and fibroblast growth factor receptor 3 (FGFR3).
Results: There were 41 (41.8%), 44 (44.9%), and 14 (14.2%) patients who have over-expressed HER2, FGFR1, and FGFR3, respectively.
In univariate analysis, significantly shorter median time to recurrence (TTR) (12.9 months vs. 49.0 months; p=0.008) and overall survival (OS) (22.3 months vs. 52.7 months; p=0.006) was found in patients with FGFR1 overexpression. By contrast, there was no difference in TTR or OS according to the HER2 and FGFR3 expression status. FGFR1 remained as a significant prognostic factor for OS with hazard ratio of 2.23 (95% confidence interval: 1.27–3.90, p=0.006) in multivariate analysis.
Conclusion: Our result showed that FGFR1 expression, but not FGFR3, is an adverse prognostic factor in muscle invasive UC patientsafter radical cystectomy. FGFR1 might be feasible for prognosis prediction and a potential therapeutic target after thorough validation in muscle invasive UC.
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참고문헌 (25)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Knowles MA / 2006 / Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? / Carcinogenesis 27:361~373
Wu XR / 2005 / Urothelial tumorigenesis: a tale of divergent pathways / Nat Rev Cancer 5:713~725
Stein JP / 2001 / Radical cystectomy in the treatment of invasive bladder cancer:long-term results in 1,054 patients / J Clin Oncol 19:666~675
von der Maase H / 2000 / Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study / J Clin Oncol 18:3068~3077
Knowles MA / 2006 / Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese? / Carcinogenesis 27:361~373
Wu XR / 2005 / Urothelial tumorigenesis: a tale of divergent pathways / Nat Rev Cancer 5:713~725
Stein JP / 2001 / Radical cystectomy in the treatment of invasive bladder cancer:long-term results in 1,054 patients / J Clin Oncol 19:666~675
von der Maase H / 2000 / Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study / J Clin Oncol 18:3068~3077
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