지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 343 - 357 (15page)
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초록· 키워드
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Müllerian inhibiting substance (MIS), also called anti-Müllerian hormone (AMH), is a member of the transforminggrowth factor-β super-family of growth and differentiation response modifiers. It is produced in immature Sertolicells in male embryos and binds to MIS/AMH receptors in primordial Müllerian ducts to cause regression of femalereproductive structures that are the precursors to the fallopian tubes, the surface epithelium of the ovaries, theuterus, the cervix, and the upper third of the vagina. Because most gynecologic tumors originate from Müllerian ductderivedtissues, and since MIS/AMH causes regression of the Müllerian duct in male embryos, it is expected to inhibitthe growth of gynecologic tumors. Purified recombinant human MIS/AMH causes growth inhibition of epithelialovarian cancer cells and cell lines in vitro and in vitro via MIS receptor-mediated mechanism. Furthermore, several linesof evidence suggest that MIS/AMH inhibits proliferation in tissues and cell lines of other MIS/AMH receptor-expressinggynecologic tumors such as cervical, endometrial, breast, and in endometriosis as well. These findings indicatethat bioactive MIS/AMH recombinant protein should be tested in patients against tumors expressing the MIS/AMHreceptor complex, perhaps beginning with ovarian cancer because it has the worst prognosis. The molecular toolsto identify MIS/AMH receptor expressing ovarian and other cancers are in place, thus, it is possible to select patientsfor treatment. An MIS/AMH ELISA exists to follow administered doses of MIS/AMH, as well. Clinical trials await theproduction of sufficient supplies of qualified recombinant human MIS/AMH for this purpose
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참고문헌 (23)
참고문헌 신청
Arango NA / 1999 / Targeted mutagenesis of the endogenous mouse Mis gene promoter:in vivo definition of genetic pathways of vertebrate sexual development / Cell 99 : 409 ~ 4
Blanchard MG / 1974 / Source of the anti-Mullerian hormone synthesized by the fetal testis: Mullerian-inhibiting activity of fetal bovine Sertoli cells in tissue culture / P
Donahoe PK / 1977 / Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes / Biol Reprod 16 : 238 ~ 243
Donahoe PK / 1977 / Mullerian inhibiting substance in human testes after birth / J Pediatr Surg 12 : 323 ~ 330
Dyche WJ / 1979 / A comparative study of the differentiation and involution of the Mullerian duct and Wolffian duct in the male and female fetal mouse / J Morphol 162 : 175 ~
Blanchard MG / 1974 / Source of the anti-Mullerian hormone synthesized by the fetal testis: Mullerian-inhibiting activity of fetal bovine Sertoli cells in tissue culture / P
Donahoe PK / 1977 / Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes / Biol Reprod 16 : 238 ~ 243
Donahoe PK / 1977 / Mullerian inhibiting substance in human testes after birth / J Pediatr Surg 12 : 323 ~ 330
Dyche WJ / 1979 / A comparative study of the differentiation and involution of the Mullerian duct and Wolffian duct in the male and female fetal mouse / J Morphol 162 : 175 ~
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