지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.1
- 발행연도
- 2021.1
- 수록면
- 25 - 32 (8page)
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초록· 키워드
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Purpose: The prognosis of young colorectal cancer (CRC) patients has not fully been addressed. The prognostic significance of systemic inflammatory markers was examined in those patients.
Methods: A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (>51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis. Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model.
Results: In the young group, NLR > 5, LMR < 2, and PNI < 45 were significantly associated with OS with univariate analyses. dNLR > 3 and those markers showed significance for PFS. LMR < 2 was a significant marker for poor PFS (hazard ratio [HR], 5.81; P = 0.020) in the multivariate analysis. In the old group, all inflammatory markers were significantly associated with OS and PFS with univariate analyses. LMR < 2 (HR, 2.66; P = 0.016) and PNI < 45 (HR, 2.14; P = 0.016) were independently associated with OS in multivariate analyses. PLR > 150 (HR, 1.45; P = 0.036) and PNI < 45 (HR, 1.73; P = 0.002) were significant markers for PFS.
Conclusion: Systemic inflammation might be one of biologic factors that influence on prognosis of young CRC.
Methods: A total of 965 patients with resectable CRC were divided into young (≤ 50 years, n = 101) and old groups (>51 years, n = 864). Neutrophil-to-lymphocyte ratio (NLR) > 5, derived NLR (dNLR) > 3, lymphocyte-to-monocyte ratio (LMR) < 2, platelet-to-lymphocyte ratio (PLR) > 150, and prognostic nutritional index (PNI) < 45 were analyzed for prognosis. Overall survival (OS) and progression-free survival (PFS) were compared using the log-rank test. A multivariate analysis was performed using a Cox proportional hazards regression model.
Results: In the young group, NLR > 5, LMR < 2, and PNI < 45 were significantly associated with OS with univariate analyses. dNLR > 3 and those markers showed significance for PFS. LMR < 2 was a significant marker for poor PFS (hazard ratio [HR], 5.81; P = 0.020) in the multivariate analysis. In the old group, all inflammatory markers were significantly associated with OS and PFS with univariate analyses. LMR < 2 (HR, 2.66; P = 0.016) and PNI < 45 (HR, 2.14; P = 0.016) were independently associated with OS in multivariate analyses. PLR > 150 (HR, 1.45; P = 0.036) and PNI < 45 (HR, 1.73; P = 0.002) were significant markers for PFS.
Conclusion: Systemic inflammation might be one of biologic factors that influence on prognosis of young CRC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36cancers in 185 countries / CA Cancer J Clin 68:394~424
Austin H / 2014 / Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening / Cancer Causes Control 25:191~201
Bailey CE / 2015 / Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010 / JAMA Surg 150:17~22
O’Connell JB / 2004 / Colorectal cancer in the young / Am J Surg 187:343~348
Khan SA / 2016 / Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients / J Pediatr Surg 51:1812~1817
Austin H / 2014 / Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening / Cancer Causes Control 25:191~201
Bailey CE / 2015 / Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010 / JAMA Surg 150:17~22
O’Connell JB / 2004 / Colorectal cancer in the young / Am J Surg 187:343~348
Khan SA / 2016 / Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients / J Pediatr Surg 51:1812~1817
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UCI(KEPA) : I410-ECN-0101-2021-514-001414485