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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 101 - 105 (5page)
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초록· 키워드
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Purpose: Metastatic breast cancer patients are usually exposed to taxane and anthracycline as neoadjuvant, adjuvant and palliative chemotherapeutic agents. This study was designed to determine the efficacy and safety of the use of a gemcitabine and cisplatin (GP) combination treatment in patients with metastatic breast cancer that were pretreated with anthracycline and taxane.
Materials and Methods: We evaluated the use of a GP regimen (1,000 mg/m² gemcitabine administered on days 1 and 8 plus 60 mg/m² cisplatin administered on day 1 every 3 weeks) in 38 breast cancer patients who had received prior chemotherapy with anthracycline and taxane as an adjuvant or neoadjuvant therapy, or as a palliative therapy.
Results: The median patient age was 49 years (age range, 35∼69 years). The overall response rate was 28.9% in 11 patients (95% confidence interval [CI], 14∼44%). The median time to progression was 5.2 months (95% CI, 3.6∼6.8 months). Median survival was 19.5 months (95% CI, 11.2∼27.8 months). Major grade 3/4 hematological toxicity was due to leukopenia (36 of 157 cycles, 23.1%). Non-hematological toxicity was rarely severe; grade1/2 nausea and vomiting were observed in 37.8% of the patients. There were no treatment related deaths.
Conclusions: Our results suggest that the use of gemcitabine plus cisplatin appears to be effective and has an acceptable toxicity profile in patients with advanced breast cancer that have been pretreated with anthracycline and taxane.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Achanta G. / 2001 / Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage / Cancer Res 61 : 8723 ~ 9
Alexopoulos A. / 2004 / Evidence for in vivo synergism between docetaxel and gemcitabine in patients with metastatic breast cancer / Ann Oncol 15 : 95 ~ 9
Blackstein M. / 2002 / Gemcitabine as first-line therapy in patients with metastatic breast cancer: a phase II trial / Oncology 62 : 2 ~ 8
Brodowicz T. / 2000 / Single-agent gemcitabine as second- and third-line treatment in metastatic breast cancer / Breast 9 : 338 ~ 42
D
Alexopoulos A. / 2004 / Evidence for in vivo synergism between docetaxel and gemcitabine in patients with metastatic breast cancer / Ann Oncol 15 : 95 ~ 9
Blackstein M. / 2002 / Gemcitabine as first-line therapy in patients with metastatic breast cancer: a phase II trial / Oncology 62 : 2 ~ 8
Brodowicz T. / 2000 / Single-agent gemcitabine as second- and third-line treatment in metastatic breast cancer / Breast 9 : 338 ~ 42
D
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