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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제40권 제2호
발행연도
2008.1
수록면
81 - 86 (6page)

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Purpose: Anthracycline and taxanes are effective agents in advanced breast cancer and prolong survival times. Some patients achieve prolongation of life with capecitabine, gemcitabine, or vinorelbine, even after failure of both anthracycline and taxanes. We analyzed the efficacy and toxicity of gemcitabine and vinorelbine combination chemotherapy in anthracycline- and taxane-pretreated advanced breast cancer. Materials and Methods: The medical records of anthracycline- and taxane-pretreated metastatic breast cancer patients who received gemcitabine and vinorelbine combination chemotherapy at the Seoul National University Hospital were reviewed. Gemcitabine (1,000 mg/m²) and vinorelbine (25 mg/m²) were administered intravenously on days 1 and 8 every 3 weeks. Results: Between 2000 and 2006, 57 patients were eligible (median age, 45 years), and the median number of previous chemotherapy regimens was 3 (range, 1∼5). The overall response rate was 30% (95% CI, 18.1∼ 41.9), and the disease control rate was 46% (PR, 30%; SD, 16%). The median duration of follow-up was 33.4 months, the median time-to-progression (TTP) was 3.9 months, and the median overall survival was 10.8 months. None of thepatients with patients with anthracycline and taxane primary resistance showed a response and the median TTP for these patients was significantly shorter than that of other patients (1.9 vs. 4.4 months; p=0.018). Although the efficacy was unsatisfactory in patients with both anthracycline and taxane primary resistance, gemcitabine and vinorelbine combination chemotherapy showed comparable efficacy in anthracyclineand/ or taxane-sensitive patients and the patients with secondary resistance, even after failure of second-line therapy. Grade 3/4 hematologic toxicities included neutropenia (18.1%) and febrile neutropenia (0.3%), and non-hematologic toxicities were tolerable. Conclusion: Gemcitabine and vinorelbine combination chemotherapy in anthracycline- and taxane-pretreated advanced breast cancer was effective and tolerable.
#Gemcitabine #Vinorelbine #Breast neoplasms #Anthracycline #Taxane

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참고문헌 (23)

참고문헌 신청
Ahn SH / 2004 / Clinical characteristics of breast cancer patients in Korea in 2000 / Arch Surg 139 : 27 ~ 30 google schola Binet S. / 1989 / In situ analysis of the action of navelbine on various types of microtubules using immunofluorescence / Semin Oncol 16 : 5 ~ 8 google schola Burris H III / 2004 / Phase II trial of trastuzumab followed by weekly paclitaxel/carboplatin as first-line treatment for patients with metastatic breast cancer / J Clin Onc google schola Carmichael J. / 1995 / Advanced breast cancer: a phase II trial with gemcitabine / J Clin Oncol 13 : 2731 ~ 6 google schola Donadio M. / 2003 / Gemcitabine and vinorelbine as second-line treatment in patients with metastatic breast cancer: A phase II study 52 : 147 ~ 52 google schola

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