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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제40권 제1호
발행연도
2008.1
수록면
22 - 26 (5page)

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Purpose: Gemcitabine is the most active agent to treat unresectable pancreatic cancer. The superiority of combining other drugs with cisplatin is still controversial; therefore, we performed a retrospective analysis of gemcitabine versus gemcitabine combined with cisplatin to determine the treatment outcomes for patients with locally advanced or metastatic pancreatic cancer. Materials and Methods: From 2001 to 2007, we enrolled 60 patients who were treated with gemcitabine or gemcitabine combined with cisplatin for locally advanced or metastatic pancreatic cancer. Gemcitabine 1, 000 mg/m2 (G) was administrated at day 1 and day 8 every 3 weeks. Cisplatin 60 mg/m2 was added at day 1 every 3 weeks to the gemcitabine schedule (GP). Results: Number of G: GP was 34: 26, locally advanced to metastatic ratio was 35% to 65% in group G and 46% to 54% in group GP. Median follow up duration was 29 months. The median number of chemotherapy cycles was 4 (range: 2∼11) for the G group, and 4 (range: 1∼ 11) for the GP group. The response rate of the G and GP groups was 17% and 11%, respectively. The progression free survival (PFS) was 4.5 months and 2.8 months, respectively, for the G and GP groups. The overall survival (OS) was 10.7 and 8.7 months respectively, for the G and GP groups, but there is no statistically significant difference of the PFS (p=0.2396) and OS (p=0.4643) between the 2 groups. The hematological toxicity profile was similar (the grade III neutropenia and thrombocytopenia was 4.4% and 3.1%, respectively, in G group, and 7.5% and 2.8%, respectively, in the GP group). But non-hematological toxicities such as skin rash, abnormal liver function and nausea/vomiting were observed in 3 patients of the GP group. On the prognostic factor analysis, no factors predicted a longer PFS and OS for both the G and GP groups. Conclusions: Gemcitabine single treatment might be more tolerable and it had the same efficacy compared to cisplatin combination treatment in this retrospective study. (Cancer Res Treat. 2008;40:22-26)
#Gemcitabine #Cisplatin #Pancreatic neoplasm

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참고문헌 (15)

참고문헌 신청
Bergman AM / 1996 / Synergistic interaction between cisplatin and gemcitabine in vitro / Clin Cancer Res 2 : 521 ~ 30 google schola Burris HA 3rd / 1997 / Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial / J google schola Colucci G. / 2002 / Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized google schola Gansauge F. / 2002 / NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial / Langenbecks Arch Surg 386 : 570 ~ 4 google schola Glimelius B. / 1996 / Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer / Ann Oncol 7 : 593 ~ 600 google schola

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