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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 274 - 279 (6page)
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초록· 키워드
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Purpose: We performed a phase II trial to evaluate the
efficacy and the safety of gemcitabine monotherapy, a
pyrimidine antimetabolite, in patients, who had previously
failed anthracycline and taxane-based chemotherapy
for the treatment of metastatic breast cancer.
Materials and Methods: Twenty-one patients with
metastatic breast cancer, which was unresponsive to
previous chemotherapy, were entered into this study.
Gemcitabine was administered at 850 mg/m2, as a 60-
minute intravenous infusion on days 1, 8 and 15. This
regimen was repeated every 28 days with G-CSF support,
but without dose reduction.
Results: Objective responses were seen in 6 of the 20
patients who were able to be evaluated (1 complete
response and 5 partial responses), with an objective
response rate of 30%. The median time to progression
was 5 (1~20) months, and the median overall survival
duration was 11 (2~21) months. The actual dose intensity
was 566.7 mg/m2/wk (range; 340~637.5 mg/m2/wk)
and the relative dose intensity was 0.89 (range; 0.40~
1.00). Toxicity was mainly hematological. Toxicities included:
grade 3 neutropenia in 20% and anemia in 5%.
Grades 3 and 4 thrombocytopenia occurred in 15% of the
patients.
Conclusion: Gemcitabine monotherapy is an effective
and safe treatment for refractory breast cancer patients
heavily treated with the anthracycline and taxane- based
regimen. (Cancer Res Treat. 2002;34:274-279)
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