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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제5호
- 발행연도
- 2021.9
- 수록면
- 317 - 323 (7page)
- DOI
- 10.4132/jptm.2021.06.28
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초록· 키워드
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Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.Methods: Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.Results: Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).Conclusions: Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.
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참고문헌 (25)
참고문헌 신청
Al-Brahim N / 2006 / Papillary thyroid carcinoma : an overview / Arch Pathol Lab Med 130:1057~1062
Ito Y / 2018 / Overall survival of papillary thyroid carcinoma patients : a singleinstitution long-term follow-up of 5897 patients / World J Surg 42:615~622
Soares P / 2014 / Prognostic biomarkers in thyroid cancer / Virchows Arch 464:333~346
Mercante G / 2009 / Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid : results of a study in 445 patients / Thyroid 19:707~716
D’Cruz AK / 2018 / Molecular markers in welldifferentiated thyroid cancer / Eur Arch Otorhinolaryngol 275:1375~1384
Ito Y / 2018 / Overall survival of papillary thyroid carcinoma patients : a singleinstitution long-term follow-up of 5897 patients / World J Surg 42:615~622
Soares P / 2014 / Prognostic biomarkers in thyroid cancer / Virchows Arch 464:333~346
Mercante G / 2009 / Prognostic factors affecting neck lymph node recurrence and distant metastasis in papillary microcarcinoma of the thyroid : results of a study in 445 patients / Thyroid 19:707~716
D’Cruz AK / 2018 / Molecular markers in welldifferentiated thyroid cancer / Eur Arch Otorhinolaryngol 275:1375~1384
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