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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 927 - 936 (10page)
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초록· 키워드
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Purpose The purpose of this study was to evaluate the impact of postmastectomy radiotherapy (PMRT) on loco-regional recurrence-free survival (LRRFS), disease-free survival (DFS), and overall survival (OS) in pT1-2N1 patients treated with taxane-based chemotherapy.
Materials and Methods We retrospectively reviewed the medical data of pathological N1 patients who were treated with modified radical mastectomy and adjuvant taxane-based chemotherapy in 12 hospitals between January 2006 and December 2010.
Results We identified 714 consecutive patients. The median follow-up duration was 69 months (range, 1 to 114 months) and the 5-year LRRFS, DFS, and OS rates were 97%, 94%, and 98%, respectively, in patients who received PMRT (PMRT [+]). The corresponding figures were 96%, 90%, and 96%, respectively, in patients who did not receive PMRT (PMRT [–]).
PMRT had no significant impact on survival. Upon multivariable analysis, only the histological grade (HG) was statistically significant as a prognostic factor for LRRFS and DFS. In a subgroup analysis of HG 3 patients, PMRT (+) showed better DFS (p=0.081).
Conclusion PMRT had no significant impact on LRRFS, DFS, or OS in pT1-2N1 patients treated with taxane- based chemotherapy. PMRT showed a marginal benefit for DFS in HG 3 patients. Randomized studies are needed to confirm the benefit of PMRT in high risk patients, such as those with HG 3.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Chang JS / 2015 / Do recent advances in diagnostic and therapeutic procedures negate the benefit of postmastectomy radiotherapy in N1 patients with a low risk of locoregiona
De Laurentiis M / 2008 / Taxane-based combinations as adjuvant chemotherapy of early breast cancer : a meta-analysis of randomized trials / J Clin Oncol 26 : 44 ~ 53
EBCTCG(Early Breast Cancer Trialists' Collaborative Group) / 2014 / Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast canc
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2005 / Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival :
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2012 / Comparisons between different polychemotherapy regimens for early breast cancer : meta-analyses of long-t
De Laurentiis M / 2008 / Taxane-based combinations as adjuvant chemotherapy of early breast cancer : a meta-analysis of randomized trials / J Clin Oncol 26 : 44 ~ 53
EBCTCG(Early Breast Cancer Trialists' Collaborative Group) / 2014 / Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast canc
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2005 / Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival :
Early Breast Cancer Trialists' Collaborative Group(EBCTCG) / 2012 / Comparisons between different polychemotherapy regimens for early breast cancer : meta-analyses of long-t
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