지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Alcohol-induced flushing syndrome is one of the alcohol hypersensitivity reactions commonly found among Asian population. This study was designed to find markers that can predict this particular propensity among Korean population and to assess the applicability of this finding to build a prediction model as forensic DNA phenotyping tool to operate in practical forensic cases. Five hundred seventy unrelated Koreans were genotyped using microfluidic technology with 24 possible candidate single nucleotide polymorphism (SNP) markers. Of the 24 candidate SNPs, four markers, rs671, rs2074356, rs4646776, and rs10849915, on chromosome 12 showed statistically significant association with P-values ranging from 1.39×10-14 to 0.004988 among our subjects. All four markers show relatively high specificity values, ranging from 0.804651 to 0.972093, presenting their capabilities as differential SNPs that can distinguish a person with or without alcohol-induced flushing syndrome. Maneuvering these candidate SNPs as well as finding additional potential markers through future studies will help building an appropriate prediction model for Koreans that can be used as supplementary tool for individual identification.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Wall TL / 1997 / Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase / Ann Intern Med 127:376~379
Baik I / 2011 / Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men / Am J Clin Nutr 93:809~816
Kim J / 2016 / No interaction with alcohol consumption, but independent effect of C12orf51 (HECTD4) on type 2 diabetes mellitus in Korean adults aged 40-69 years: the KoGES_Ansan and Ansung Study / PLoS One 11:e0149321
Eriksson CJ / 2001 / Functional relevance of human adh polymorphism / Alcohol Clin Exp Res 25(5 Suppl ISBRA):157S~163S
Sherva R / 2009 / Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans / Alcohol Clin Exp Res 33:848~857
Baik I / 2011 / Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men / Am J Clin Nutr 93:809~816
Kim J / 2016 / No interaction with alcohol consumption, but independent effect of C12orf51 (HECTD4) on type 2 diabetes mellitus in Korean adults aged 40-69 years: the KoGES_Ansan and Ansung Study / PLoS One 11:e0149321
Eriksson CJ / 2001 / Functional relevance of human adh polymorphism / Alcohol Clin Exp Res 25(5 Suppl ISBRA):157S~163S
Sherva R / 2009 / Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans / Alcohol Clin Exp Res 33:848~857
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