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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis. Methods: A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269).
The identified SNPs of osteoporosis-related traits in Korean subjects were included in the replication analysis using Chinese (n=2,327) and Japanese (n=768) cohorts. Results: A total of 17 SNPs were associated with low BMD in Korean subjects. Specifically, 9, 6, 9, and 5 SNPs were associated with the presence of osteoporosis, non-vertebral fractures, vertebral fractures, and any fracture, respectively. Collectively, 35 of the 95 SNPs (36.8%) were associated with one or more osteoporosis-related trait in Korean subjects. Of the 35 SNPs, 19 SNPs (54.3%) were also associated with one or more osteoporosis-related traits in East Asian populations. Twelve SNPs were associated with low BMD in the Chinese and Japanese cohorts. Specifically, 3, 4, and 2 SNPs were associated with the presence of hip fractures, vertebral fractures, and any fracture, respectively. Conclusions: Our results identified the common SNPs of osteoporosis-related traits in both Caucasian and East Asian populations. These SNPs should be further investigated to assess whether they are true genetic markers of osteoporosis.
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참고문헌 (22)
참고문헌 신청
NIH Consensus Development Panel on Osteoporosis, Prevention, Diagnosis and Therapy / 2001 / Osteoporosis prevention, diagnosis, and therapy / JAMA 285:785~795
Choi HJ / 2012 / Burden of osteoporosis in adults in Korea : a national health insurance database study / J Bone Miner Metab 30:54~58
Hong-Wen Deng / 2014 / Genome-wide Association Studies for Osteoporosis: A 2013 Update / 대한골대사학회지 21(2):98~114
Ralston SH / 2010 / Genetics of osteoporosis / Endocr Rev 31:629~662
Gullberg B / 1997 / World-wide projections for hip fracture / Osteoporos Int 7:407~413
Choi HJ / 2012 / Burden of osteoporosis in adults in Korea : a national health insurance database study / J Bone Miner Metab 30:54~58
Hong-Wen Deng / 2014 / Genome-wide Association Studies for Osteoporosis: A 2013 Update / 대한골대사학회지 21(2):98~114
Ralston SH / 2010 / Genetics of osteoporosis / Endocr Rev 31:629~662
Gullberg B / 1997 / World-wide projections for hip fracture / Osteoporos Int 7:407~413
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