The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine

Ande M. Jakoi; Gurpal Pannu; Anthony D’Oro; Zorica Buser; Martin H. Pham; Neil N. Patel; Patrick C. Hsieh; John C. Liu; Frank L. Acosta; Raymond Hah; Jeffrey C. Wang

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저자정보: Ande M. Jakoi (University of Southern California) Gurpal Pannu (Drexel University) Anthony D’Oro (University of Southern California) Zorica Buser (University of Southern California) Martin H. Pham (University of Southern California) Neil N. Patel (University of Southern California) Patrick C. Hsieh (University of Southern California) John C. Liu (University of Southern California) Frank L. Acosta (University of Southern California) Raymond Hah (University of Southern California) Jeffrey C. Wang (University of Southern California)

저널정보: 대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.11 No.3

발행연도: 2017.1

수록면: 337 - 347 (11page)

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Study Design: Retrospective analysis of a nationwide private insurance database. Chi-square analysis and linear regression models were utilized for outcome measures. Purpose: The purpose of this study was to investigate any relationship between lumbar degenerative disc disease, diabetes, obesity and smoking tobacco. Overview of Literature: Diabetes, obesity, and smoking tobacco are comorbid conditions known to individually have effect on degenerative disc disease. Most studies have only been on a small populous scale. No study has yet to investigate the combination of these conditions within a large patient cohort nor have they reviewed the combination of these conditions on degenerative disc disease. Methods: A retrospective analysis of insurance billing codes within the nationwide Humana insurance database was performed, using PearlDiver software (PearlDiver, Inc., Fort Wayne, IN, USA), to identify trends among patients diagnosed with lumbar disc degenerative disease with and without the associated comorbidities of obesity, diabetes, and/or smoking tobacco. Patients billed for a comorbidity diagnosis on the same patient record as the lumbar disc degenerative disease diagnosis were compared over time to patients billed for lumbar disc degenerative disease without a comorbidity. There were no sources of funding for this manuscript and no conflicts of interest. Results: The total number and prevalence of patients (per 10,000) within the database diagnosed with lumbar disc degenerative disease increased by 241.4% and 130.3%, respectively. The subsets of patients within this population who were concurrently diagnosed with either obesity, diabetes, tobacco use, or a combination thereof, was significantly higher than patients diagnosed with lumbar disc degenerative disease alone (p <0.05 for all). The number of patients diagnosed with lumbar disc degenerative disease and smoking rose significantly more than patients diagnosed with lumbar disc degenerative disease and either diabetes or obesity (p <0.05). The number of patients diagnosed with lumbar disc degenerative disease, smoking and obesity rose significantly more than the number of patients diagnosed with lumbar disc degenerative disease and any other comorbidity alone or combination of comorbidities (p <0.05). Conclusions: Diabetes, obesity and cigarette smoking each are significantly associated with an increased diagnosis of lumbar degenerative disc disease. The combination of smoking and obesity had a synergistic effect on increased rates of lumbar degenerative disc disease. Patient education and preventative care is a vital goal in prevention of degenerative disc disease within the general population.

참고문헌 (4)

참고문헌 신청

Katz JN / 2006 / Lumbar disc disorders and low-back pain: socioeconomic factors and consequences / J Bone Joint Surg Am 88(Suppl 2):21~24

Masuda K / 2008 / Biological repair of the degenerated intervertebral disc by the injection of growth factors / Eur Spine J 17(Suppl 4):441~451

Iatridis JC / 2006 / Effects of mechanical loading on intervertebral disc metabolism in vivo / J Bone Joint Surg Am 88(Suppl 2):41~46

Metz LN / 2012 / Does diabetes cause the intervertebral disc to degenerate? / Spine J 12(Suppl):S74~S75

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Ande M. Jakoi

소속기관 University of Southern California

주요연구분야 의약학 > 임상의학 > 정형외과학

논문수 1 이용수 0

Gurpal Pannu

소속기관 Drexel University

주요연구분야 의약학 > 임상의학 > 정형외과학

논문수 1 이용수 0

Anthony D’Oro

소속기관 University of Southern California

주요연구분야 의약학 > 임상의학 > 정형외과학

논문수 3 이용수 0

Zorica Buser

소속기관 University of Southern California

주요연구분야 의약학 > 임상의학 > 정형외과학

논문수 3 이용수 0

Martin H. Pham