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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 357 - 366 (10page)
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초록· 키워드
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Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open field after SPS. IBU administration significantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis factor-α, interleukin-1β, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These findings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Zhang LM / 2015 / Anxiolytic effects of ketamine in animal models of posttraumatic stress disorder / Psychopharmacology(Berl) 232:663~672
Brunello N / 2001 / Posttraumatic stress disorder : diagnosis and epidemiology, comorbidity and social consequences, biology and treatment / Neuropsychobiology 43:150~162
Nemeroff CB / 2006 / Posttraumatic stress disorder : a state-of-the-science review / J Psychiatr Res 40:1~21
Ji MH / 2014 / Dexmedetomidine alleviates anxiety-like behaviors and cognitive impairments in a rat model of post-traumatic stress disorder / Prog Neuropsychopharmacol Biol Psychiatry 54:284~288
Rau V / 2005 / Stress-induced enhancement of fear learning : an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
Brunello N / 2001 / Posttraumatic stress disorder : diagnosis and epidemiology, comorbidity and social consequences, biology and treatment / Neuropsychobiology 43:150~162
Nemeroff CB / 2006 / Posttraumatic stress disorder : a state-of-the-science review / J Psychiatr Res 40:1~21
Ji MH / 2014 / Dexmedetomidine alleviates anxiety-like behaviors and cognitive impairments in a rat model of post-traumatic stress disorder / Prog Neuropsychopharmacol Biol Psychiatry 54:284~288
Rau V / 2005 / Stress-induced enhancement of fear learning : an animal model of posttraumatic stress disorder / Neurosci Biobehav Rev 29:1207~1223
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