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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 325 - 332 (8page)
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초록· 키워드
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Background/Aims: Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut microbiota in brain-gut axis pathogenesis during coincident depression and IBS. Methods: Rat models of depression were induced using our shuttle box method of learned helplessness. Visceral hypersensitivity was evaluated by colorectal distension (CRD) to diagnose IBS. Gut microbiota compositions were analyzed using highthroughput sequencing. In the subanalysis of rats without depression-like symptoms, rats with posttraumatic stress disorder (PTSD) were also examined. Results: The threshold value of CRD in depressed rats was significantly lower than that in control rats. Microbial community analysis of cecal microbiota showed that the relative abundance of Clostridiales incertae sedis, the most prevalent microbe, was significantly lower in depressed rats than in control rats. The distribution pattern of the microbiota clearly differed between depressed rats and control rats. Neither visceral hypersensitivity nor the composition of gut microbiota was altered in rats with PTSDlike phenotypes. Conclusions: Our rat model of depression is useful for clarifying the effect of depression on IBS and suggests that depression itself, rather than specific stressors, promotes the onset of IBS. Further, we provided evidence that various psychiatric diseases, viz., depression and PTSD, are associated with unique gut microbiota profiles, which could differentially affect the onset and progression of coincident IBS.
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참고문헌 (30)
참고문헌 신청
Kanazawa M / 2004 / Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress / Dig Dis Sci 49:1046~1053
Koloski NA / 2012 / The brain: gut pathway in functional gastrointestinal disorders is bidirectional. A 12-year prospective population-based study / Gut 61:1284~1290
Grenham S / 2011 / Brain-gut-microbe communication in health and disease / Front Physiol 2:94
Tap J / 2017 / Identification of an intestinal microbiota signature associated with severity of irritable bowel syndrome / Gastroenterology 152:111~123
Rodiño-Janeiro BK / 2018 / A review of microbiota and irritable bowel syndrome : future in therapies / Adv Ther 35:289~310
Koloski NA / 2012 / The brain: gut pathway in functional gastrointestinal disorders is bidirectional. A 12-year prospective population-based study / Gut 61:1284~1290
Grenham S / 2011 / Brain-gut-microbe communication in health and disease / Front Physiol 2:94
Tap J / 2017 / Identification of an intestinal microbiota signature associated with severity of irritable bowel syndrome / Gastroenterology 152:111~123
Rodiño-Janeiro BK / 2018 / A review of microbiota and irritable bowel syndrome : future in therapies / Adv Ther 35:289~310
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