지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives：There are evidences of apoptotic neuronal cell death in Alzheimer’s disease (AD). Recent studies suggested AD pathogenesis in the central nervous system as well as in peripheral lymphocytes. The object of this study is to compare the cell viability and the proliferation activity in AD patients with healthy normal control by using peripheral lymphocytes.
Methods：We analyzed the cell viability and the proliferation activity of phytohemagglutinin (PHA)-activated lymphocytes from 73 AD patients and 31 normal contols. The cell viability and the proliferation activity were measured at baseline (T0), 24 hours (T24), 48 hours (T48), 72 hours (T72), 96 hours (T96), by the tryphan blue method and the BrdU proliferation activity method, respectively.
Results：The cell viability of PHA-activated peripheral lymphocytes in AD patients was significantly decreased at T72, T96 compared with healthy controls (F=8.034, p<0.001). In AD patients, the decline of proliferation activity appeared in earlier than healthy normal controls.
Conclusion：This study suggests that there is a decreased cell viability and the proliferation activity of peripheral lymphocytes in AD patients. These finding may be related with the increased apoptosis in Alzheimer’s disease.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1991 / BDI,SDS,MMPI-D 척도의 신뢰도 및 타당도에 대한 연구 10 : 98 ~ 113
/ 1993 / An empirical evaluation of the Global Deterioration Scalefor staging Alzheimer’s disease 150 : 680 ~ 682
/ 1995 / A potential role for apoptosis in neurodegenerationand Alzheimer’s disease 10 : 19 ~ 45
/ 1995 / Usefulness of the Clinical Dementia Rating scale in screening fordementia 7 : 17 ~ 24
/ 1996 / Immune-activation model in Alzheimer disease 28 : 105 ~ 111
/ 1993 / An empirical evaluation of the Global Deterioration Scalefor staging Alzheimer’s disease 150 : 680 ~ 682
/ 1995 / A potential role for apoptosis in neurodegenerationand Alzheimer’s disease 10 : 19 ~ 45
/ 1995 / Usefulness of the Clinical Dementia Rating scale in screening fordementia 7 : 17 ~ 24
/ 1996 / Immune-activation model in Alzheimer disease 28 : 105 ~ 111
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