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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 68 - 71 (4page)
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Objective: We evaluated cell viability and proliferation activity of peripheral lymphocytes as potential models of neuronal death in Alzheimer’s disease (AD).
Methods: We analyzed the cell viability and proliferation activity of phytohemagglutinin (PHA)-activated lymphocytes from 68 AD patients and 33 normal controls. The cellular measures were made at baseline (0 hr), 24 hrs, 48 hrs, 72 hrs, and 96 hrs after PHA stimulation.
Results: Cell viability in the AD patients was significantly decreased at 72 hrs and 96 hrs, compared with the normal controls. The declining ramp of the proliferation activity from 48 hrs to 72 hrs after PHA stimulation was significantly related to cell viability at 72 hrs and at 96 hrs in the AD patients.
Conclusion: Lymphocytes from patients with AD have altered viability and proliferation characteristics in culture following PHA stimulation. These findings suggest that lymphocytes may be used as a peripheral tissue model of cell cycle dysregulation in AD.
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참고문헌 (13)
참고문헌 신청
Becker EB / 2004 / Cell cycle regulation of neuronal apoptosis in development and disease / Prog Neurobiol 72 : 1 ~ 25
Cotman CW / 1995 / A potential role for apoptosis in neurodegeneration and Alzheimer’s disease / Mol Neurobiol 10 : 19 ~ 45
Cummings JL / 2002 / Alzheimer disease / JAMA 287 : 2335 ~ 2338
Fassbender K / 2004 / The LPS receptor (CD14) links innate immunity with Alzheimer’s disease / Faseb J 18 : 203 ~ 205
Folstein MF / 1975 / Mini-mental state. A practical method for grading the cognitive state of patients for the clinician / J Psychiat Res 12 : 189 ~ 198
Cotman CW / 1995 / A potential role for apoptosis in neurodegeneration and Alzheimer’s disease / Mol Neurobiol 10 : 19 ~ 45
Cummings JL / 2002 / Alzheimer disease / JAMA 287 : 2335 ~ 2338
Fassbender K / 2004 / The LPS receptor (CD14) links innate immunity with Alzheimer’s disease / Faseb J 18 : 203 ~ 205
Folstein MF / 1975 / Mini-mental state. A practical method for grading the cognitive state of patients for the clinician / J Psychiat Res 12 : 189 ~ 198
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