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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제9권 제3호
- 발행연도
- 2010.1
- 수록면
- 88 - 92 (5page)
이용수
초록· 키워드
오류제보하기
Background: Circulating CD34-positive cells constitute the endothelial progenitor cell population,differentiate into endothelial cells, and contribute to mammalian brain regeneration.
Given the vascular endothelial pathogenesis of Alzheimer’s disease (AD), we investigated the levels of CD34+ cells in AD patients. Methods: Sixty-six consecutive patients with probable AD (clinical dementia rating scale 1) and 22 age-matched control subjects were enrolled. CD34+cells were counted in their peripheral blood samples and analyzed in comparison with their clinical characteristics. Results: The AD patients had significantly lower numbers of CD34-positive cells than control subjects. However, the number of CD34-positive cells was not correlated with clinical characteristics of AD patients, including Mini Mental State Examination (MMSE)score, Framingham risk score, body-mass index, and changes in MMSE during 3 months.
Conclusions: AD patients have diminished circulating CD34-positive cells, suggesting the reduced regenerative support from the peripheral blood in AD patients.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Asahara T / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275 : 964 ~ 967
Benarroch EE / 2007 / Neurovascular unit dysfunction: a vascular component of Alzheimer disease? / Neurology 68 : 1730 ~ 1732
Breteler MM / 2000 / Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective / Neurobiol Aging 21 : 153 ~ 160
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363 : 1432 ~ 1437
Dimmeler S / 2001 / HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway / J Clin Invest 108 : 391 ~ 397
Benarroch EE / 2007 / Neurovascular unit dysfunction: a vascular component of Alzheimer disease? / Neurology 68 : 1730 ~ 1732
Breteler MM / 2000 / Vascular risk factors for Alzheimer’s disease: an epidemiologic perspective / Neurobiol Aging 21 : 153 ~ 160
Cogle CR / 2004 / Bone marrow transdifferentiation in brain after transplantation: a retrospective study / Lancet 363 : 1432 ~ 1437
Dimmeler S / 2001 / HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway / J Clin Invest 108 : 391 ~ 397
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