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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.10
- 수록면
- 90 - 100 (11page)
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초록· 키워드
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Capicua (CIC) is a transcriptional repressor that regulates several developmental processes. CIC deficiency results in lymphoproliferative autoimmunity accompanied by expansion of CD44<SUP>hi</SUP>CD62L<SUP>lo</SUP> effector/memory and follicular Th cell populations. Deletion of Cic alleles in hematopoietic stem cells (Vav1-Cre-mediated knockout of Cic) causes more severe autoimmunity than that caused by the knockout of Cic in CD4<SUP>+</SUP>CD8<SUP>+</SUP> double positive thymocytes (Cd4-Cre-mediated knockout of Cic). In this study, we compared splenic CD4<SUP>+</SUP> T cell activation and proliferation between whole immune cell-specific Cic-null (Cic<SUP>f/f</SUP>;Vav1-Cre) and T cell-specific Cic-null (Cic<SUP>f/f</SUP>;Cd4-Cre) mice. Hyperactivation and hyperproliferation of CD4<SUP>+</SUP> T cells were more apparent in Cic<SUP>f/f</SUP>;Vav1-Cre mice than in Cic<SUP>f/f</SUP>;Cd4-Cre mice. Cic<SUP>f/f</SUP>;Vav1-Cre CD4<SUP>+</SUP> T cells more rapidly proliferated and secreted larger amounts of IL-2 upon TCR stimulation than did Cic<SUP>f/f</SUP>;Cd4-Cre CD4<SUP>+</SUP> T cells, while the TCR stimulation-induced activation of the TCR signaling cascade and calcium flux were comparable between them. Mixed wildtype and Cic<SUP>f/f</SUP>;Vav1-Cre bone marrow chimeras also exhibited more apparent hyperactivation and hyperproliferation of Cic-deficient CD4<SUP>+</SUP> T cells than did mixed wild-type and Cic<SUP>f/f</SUP>;Cd4-Cre bone marrow chimeras. Taken together, our data demonstrate that CIC deficiency at the beginning of T cell development endows peripheral CD4<SUP>+</SUP> T cells with enhanced T cell activation and proliferative capability.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2020-517-001556074