지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 289 - 295 (7page)
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초록· 키워드
오류제보하기
Flow cytometric immunophenotyping of peripheral blood lymphocyte subsets is a powerful tool for evaluating cellular immunity and monitoring immune-mediated diseases. The numbers and proportions of blood lymphocyte subsets are influenced by factors such as gender, age, ethnicity, and lifestyle. This study aimed to establish reference ranges for peripheral blood lymphocyte subsets in a healthy Korean population. Blood samples from 294 healthy adults were collected. Lymphocyte subsets were analyzed using a single-platform method with a flow cytometer; white blood cells and lymphocytes were analyzed using an automated hematology analyzer. The mean value of the white blood cell count was 5,665 cells/μl, and the mean values of the subtype counts (percentages) were as follows: lymphocytes, 1,928 cells/μl (35.08%); CD3<SUP>＋</SUP> cells, 1,305 cells/μl (67.53%); CD3<SUP>＋</SUP>CD4<SUP>＋</SUP> cells, 787 cells/μl (40.55%); CD3<SUP>＋</SUP>CD8<SUP>＋</SUP> cells, 479 cells/μl (25.23%); CD3<SUP>?</SUP>CD19<SUP>＋</SUP> cells, 203 cells/μl (10.43%); and CD3<SUP>?</SUP>CD56<SUP>＋</SUP> cells, 300 cells/μl (15.63%). Additionally, the CD4<SUP>＋</SUP>/CD8<SUP>＋</SUP> ratio was 1.81. In this study, gender and age significantly influenced blood lymphocyte subsets. Our results demonstrate that, as with other populations, a healthy Korean population has its own, region-specific, lymphocyte subset reference ranges.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Bleesing, J. J. / 2001 / Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome / Blood 98 : 2466 ~ 2473
2. [학술지(정기간행물)] - Barnett, D / 2008 / CD4 immunophenotyping in HIV infection / Nat. Rev. Microbiol 6 : S7 ~ S15
3. [학술지(정기간행물)] - Lacombe, F. / 1997 / Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia / Leukemia 11 : 1878 ~ 1886
4. [학술지(정기간행물)] - Lee, B. W. / 1996 / Age- and sex-related changes in lymphocyte subpopulations of healthy Asian subjects: from birth to adulthood / Cytometry 26 : 8 ~ 15
5. [학술지(정기간행물)] - Jalla, S / 2004 / Enumeration of lymphocyte subsets using flow cytometry: Effect of storage before and after staining in a developing country setting / Indian J. Clin. Biochem 19 : 95 ~ 99
2. [학술지(정기간행물)] - Barnett, D / 2008 / CD4 immunophenotyping in HIV infection / Nat. Rev. Microbiol 6 : S7 ~ S15
3. [학술지(정기간행물)] - Lacombe, F. / 1997 / Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia / Leukemia 11 : 1878 ~ 1886
4. [학술지(정기간행물)] - Lee, B. W. / 1996 / Age- and sex-related changes in lymphocyte subpopulations of healthy Asian subjects: from birth to adulthood / Cytometry 26 : 8 ~ 15
5. [학술지(정기간행물)] - Jalla, S / 2004 / Enumeration of lymphocyte subsets using flow cytometry: Effect of storage before and after staining in a developing country setting / Indian J. Clin. Biochem 19 : 95 ~ 99
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UCI(KEPA) : I410-ECN-0101-2016-511-001754193