지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 296 - 302 (7page)
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초록· 키워드
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Background and Purpose Perampanel is the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor antagonist developed to treat epilepsy. The effects of either rapid or slow dose titration on adverse events remain to be elucidated. Methods Eighty-five patients received perampanel between March 2016 and August 2016. Patients were divided into two groups according to their dosing schedule: rapid dose titration (2-mg increments at intervals of 1 to 2 weeks) and slow dose titration (2-mg increments at intervals of at least 3 weeks). Seizure frequency and adverse events were analyzed over 3 months. Results Adverse events were reported by 47 (58%) of the 81 patients analyzed, with 12 (15%) patients discontinuing perampanel due to adverse events. Common adverse events included dizziness (n=30, 37%), aggressive mood and behavior (n=19, 24%), gait disturbance (n=16, 20%), and sleep problems (n=10, 12.4%). The overall adverse events were similar in the slow-titration group (38 of 61 patients) and the rapid-titration group (8 of 20 patients, p=0.081). However, none of the 20 patients in the slow-titration group experienced gait disturbance, compared with 16 of the 61 patients in the rapid-titration group (p=0.009), while appetite change was experienced by 4 patients in the slow-titration group but only 1 in the rapid-titration group (p=0.003). No relationship was noted between adverse events and the maximum dose of perampanel (p=0.116). Sex differences were observed, with the response to perampanel being better and the rate of adverse events being higher in females (p=0.015 and p=0.046, respectively). Conclusions Slow titration of perampanel may reduce perampanel-related adverse events.
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참고문헌 (18)
참고문헌 신청
Rogawski MA / 2011 / Revisiting AMPA receptors as an antiepileptic drug target / Epilepsy Curr 11:56~63
French JA / 2012 / Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304 / Neurology 79:589~596
French JA / 2013 / Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305 / Epilepsia 54:117~125
Krauss GL / 2012 / Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures / Neurology 78:1408~1415
De Liso P / 2016 / Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies: an Italian observational multicenter study / Epilepsy Res 127:93~100
French JA / 2012 / Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304 / Neurology 79:589~596
French JA / 2013 / Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: results of randomized global phase III study 305 / Epilepsia 54:117~125
Krauss GL / 2012 / Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures / Neurology 78:1408~1415
De Liso P / 2016 / Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies: an Italian observational multicenter study / Epilepsy Res 127:93~100
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