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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 142 - 148 (7page)
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초록· 키워드
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Background: This study was conducted to compare glycaemic control with insulin detemir administered according to two titration algorithms (3-0-3 and 2-4-6-8) after 20 weeks of treatment in subjects with type 2 diabetes mellitus inadequately controlled on metformin. Methods: This was a 20-week, randomised, multicentre, open-labelled, treat-to-target trial. Forty-six patients were randomised in a1:1 manner to either the 3-0-3 (G3, n=23) or 2-4-6-8 (G2, n=23) algorithm. The primary endpoint was change of haemoglobin A1c(HbA1c), and the secondary safety endpoint included hypoglycaemic events. Results: After 20 weeks, HbA1c decreased similarly in the G3 and G2 groups, with a mean change of −0.9% from baseline. Themean change in fasting plasma glucose was numerically similar in both groups. The hypoglycaemia event rate per 100-patient-yearsof exposure (r) in the G2 group (r=1,427) was higher than that in the G3 group (r=807). Conclusion: Both treatment groups had numerically similar HbA1c reductions. A trend towards fewer hypoglycaemia episodes afterdose stabilisation was seen with the simpler G3. Clinically, this may be an important observation, as a simpler titration algorithmmay support self-management and maintenance of insulin therapy.
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참고문헌 (13)
참고문헌 신청
Home P / 2011 / An observational non-interventional study of people with diabetes beginning or changed to insulin analogue therapy in non-Western countries : the A1chieve study / Diabetes Res Clin Pract 94:352~363
Riddle MC / 2003 / The treat-to-target trial : randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients / Diabetes Care 26:3080~3086
Philis-Tsimikas A / 2006 / Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes / Clin Ther 28:1569~1581
Jabbour S / 2008 / Primary care physicians and insulin initiation: multiple barriers, lack of knowledge or both? / Int J Clin Pract 62:845~847
Fajardo Montanana C / 2008 / Less weight gain and hypoglycaemia with once-daily insulin detemir than NPH insulin in intensification of insulin therapy in overweight type 2 diabetes patients : the PREDICTIVE BMI clinical trial / Diabet Med 25:916~923
Riddle MC / 2003 / The treat-to-target trial : randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients / Diabetes Care 26:3080~3086
Philis-Tsimikas A / 2006 / Comparison of once-daily insulin detemir with NPH insulin added to a regimen of oral antidiabetic drugs in poorly controlled type 2 diabetes / Clin Ther 28:1569~1581
Jabbour S / 2008 / Primary care physicians and insulin initiation: multiple barriers, lack of knowledge or both? / Int J Clin Pract 62:845~847
Fajardo Montanana C / 2008 / Less weight gain and hypoglycaemia with once-daily insulin detemir than NPH insulin in intensification of insulin therapy in overweight type 2 diabetes patients : the PREDICTIVE BMI clinical trial / Diabet Med 25:916~923
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