지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제2호
- 발행연도
- 2015.1
- 수록면
- 124 - 127 (4page)
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초록· 키워드
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Purpose: Adverse cutaneous reactions to antituberculous drugs (ATD), such as maculopapular eruption (MPE), are the most common causes of discontinuation of scheduled treatment of tuberculosis. We previously reported that tumor necrosis factor (TNF)-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This study aimed to investigate associations between TNF-α -308G/A and ATD-induced MPE.
Methods: Patients with ATD-induced MPE and controls without any adverse reactions to ATD were recruited from the database of the Adverse Drug Reaction Pharmacogenomic Research Group database of Korea. We compared the genotype frequency of TNF-α -308G/A between patients with ATD-induced MPE and ATD-tolerant controls.
Results: A total of 69 patients with ATD-induced MPE and 229 control subjects were enrolled for this study. There were no significant differences in genotype frequency between the patients and the controls, suggesting lack of associations between TNF-α -308G/A and ATD-induced MPE.
Conclusion: The TNF-α genetic polymorphism -308G/A may not be related to the development of ATD-induced MPE, in contrast to ATD-induced hepatitis. These findings suggest that associations between TNF-α -308G/A and ATD-induced adverse reactions can be phenotype-specific.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
American Thoracic Society / 2003 / Treatment of tuberculosis : 1 ~ 77
Dossing M / 1996 / Liver injury during antituberculosis treatment : an 11-year study / Tuber Lung Dis 77 : 335 ~ 340
Elahi MM / 2009 / Tumor necrosis factor alpha-308 gene locus promoter polymorphism : an analysis of association with health and disease / Biochim Biophys Acta 1792 : 163 ~ 1
Fernandez TD / 2008 / Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs / Allergy 63 : 712 ~ 719
Kim SH / 2010 / GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans / Tuberculosis(Edinb) 90 : 39 ~ 43
Dossing M / 1996 / Liver injury during antituberculosis treatment : an 11-year study / Tuber Lung Dis 77 : 335 ~ 340
Elahi MM / 2009 / Tumor necrosis factor alpha-308 gene locus promoter polymorphism : an analysis of association with health and disease / Biochim Biophys Acta 1792 : 163 ~ 1
Fernandez TD / 2008 / Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs / Allergy 63 : 712 ~ 719
Kim SH / 2010 / GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans / Tuberculosis(Edinb) 90 : 39 ~ 43
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