Successful salvage treatment of acute graft-versus-host disease after liver transplantation by withdrawal of immunosuppression : a case report :a case report

Wei Qiu; Guo-Yue Lv; Chao Jiang; Ping Zhang; Xiao-Dong Sun; Xiao-Ju Shi; Xue-Yan Liu; Guang-Yi Wang

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자료유형: 학술저널

저자정보: Wei Qiu (First Hospital of Jilin University) Guo-Yue Lv (First Hospital of Jilin University) Chao Jiang (First Hospital of Jilin University) Ping Zhang (First Hospital of Jilin University) Xiao-Dong Sun (First Hospital of Jilin University) Xiao-Ju Shi (Department of Hepato-biliary Pancreatic Surgery) Xue-Yan Liu (Jilin University) Guang-Yi Wang (First Hospital of Jilin University)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제20권 제1호

발행연도: 2016.2

수록면: 38 - 43 (6page)

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Acute graft-versus-host disease (GVHD) following liver transplantation is a rare but fatal complication. The correct diagnosis and management of GVHD after liver transplantation are still major challenges. Herein, we reported successful salvage treatment of acute GVHD by withdrawal of immunosuppression in a patient who presented with fever, skin rashes, and decreased blood cell counts after liver transplantation. This case highlights the need for awareness of drug-induced liver injury if liver function tests are elevated during treatment, especially in patients taking multiple potentially hepatotoxic drugs, such as broad-spectrum antibiotics. When occurs, an artificial liver support system is a useful tool to provide temporary support of liver function for the patient in the event of drug-induced liver injury.

#Graft-versus-host disease #Liver transplantation #Drug-induced liver injury

참고문헌 (18)

참고문헌 신청

Faraci M, Caviglia I, Biral E, Morreale G, Giardino S, Garbarino L, et al. Acute graft-versus-host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single-center experience during 10 yr. Pediatr Transplant 2012;16:887-893.

Burdick JF, Vogelsang GB, Smith WJ, Farmer ER, Bias WB, Kaufmann SH, et al. Severe graft-versus-host disease in a liver- transplant recipient. N Engl J Med 1988;318:689-691.

Chen XB, Yang J, Xu MQ, Wen TF, Yan LN. Unsuccessful treatment of four patients with acute graft-vs-host disease after liver transplantation. World J Gastroenterol 2012;18:84-89.

Rogulj IM, Deeg J, Lee SJ. Acute graft versus host disease after orthotopic liver transplantation. J Hematol Oncol 2012;5:50.

Perri R, Assi M, Talwalkar J, Heimbach J, Hogan W, Moore SB, et al. Graft vs. host disease after liver transplantation: a new approach is needed. Liver Transpl 2007;13:1092-1099.

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