지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제42권 제6호
- 발행연도
- 2008.1
- 수록면
- 358 - 364 (7page)
이용수
초록· 키워드
오류제보하기
Background : Expression of CXCR4 chemokine receptor, initially described to be involved in the homing of lymphocytes in inflammatory tissue, on breast cancer cell lines is associated with the development of lung metastases. In the present study, we evaluated CXCR4 expression in patients with non-small cell lung cancer (NSCLC). Methods : Tissue microarray blocks were constructed from 408 formalin-fixed, paraffin-embedded NSCLC samples and analyzed via immunohistochemical staining. Results : We observed CXCR4 expression in 214 (66.3%) of the 323 tumors with cytoplasmic or nuclear staining patterns. These tumors were then divided into 109 negative, 166 weak-positive and 48 strong-positive expression groups. Strong expression of CXCR4 correlated with NSCLC recurrence (p=0.047) and distant metastasis (p=0.035). However, lymph node metastasis (p=0.683) and locoregional recurrence (p=0.856) were not associated with CXCR4 expression. Interestingly, the median overall survival times relative to CXCR4 expression were 71 months in the CXCR4-negative group, 43 months in the weakly positive CXCR4 group and 23 months in the strongly positive CXCR4 group. Strongly positive CXCR4 staining was associated with significantly worse outcomes (p=0.005, log-rank test). Conclusions : Expression of CXCR4 was associated with distant NSCLC metastases and shorter survival times.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Baggiolini M. / 1998 / Chemokines and leukocyte traffic / Nature 392 : 565 ~ 568
Balkwill F. / 2004 / The significance of cancer cell expression of the chemokine receptor CXCR4 / Semin Cancer Biol 14 : 171 ~ 179
Burger M / 2003 / Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells / Oncogene 22
Fidler IJ. / 1990 / Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture / Cancer Res 50 : 6130 ~ 6138
Fidler IJ. / 1999 / Critical determinants of cancer metastasis: rationale for therapy / Cancer Chemother Pharmacol 43 : 3 ~ 10
Balkwill F. / 2004 / The significance of cancer cell expression of the chemokine receptor CXCR4 / Semin Cancer Biol 14 : 171 ~ 179
Burger M / 2003 / Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells / Oncogene 22
Fidler IJ. / 1990 / Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture / Cancer Res 50 : 6130 ~ 6138
Fidler IJ. / 1999 / Critical determinants of cancer metastasis: rationale for therapy / Cancer Chemother Pharmacol 43 : 3 ~ 10
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Characterization of atypical chemokine receptor CXCR7 signaling pathway
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Expression of Chemokines and Chemokine Receptors in Brain Tumor Tissue Derived Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy
Journal of Pathology and Translational Medicine
2018 .01
-
Differential Expression of CXCR4 in Conventional High-grade and Low-grade Central Osteosarcoma and Its Prognostic Implications
대한골관절종양학회지
2012 .01
-
Effect of CXCR4 and CD133 Co-expression on the Prognosis of Patients with Stage II~III Colon Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Role of CXCR7 and Effects on CXCL12 in SiHa Cells and Upregulation in Cervical Squamous Cell Carcinomas in Uighur Women
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Expression of the CXCL12/SDF-1 Chemokine Receptor CXCR7 in Human Brain Tumours
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
관절연골 재생을 위한 골수유래 중간엽 줄기세포의 특이적 케모카인
OSTEOPOROSIS
2011 .01
-
Study on the Relationship Between CXCR4 Expression and Perineural Invasion in Pancreatic Cancer
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Cytoplasmic Trapping of CXCR4 in Hepatocellular Carcinoma Cell Lines
Cancer Research and Treatment
2008 .01
-
Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma
Gut and Liver
2014 .01
-
치과 생체재료에 의한 사람 치수세포의 SDF-1과 CXCR4 발현
대한치과재료학회 학술대회
2010 .11
-
TRAIL Suppresses Human Breast Cancer Cell Migration via MADD/CXCR7
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
CXCL12-CXCR4 axis plays an important role in correct patterning of the aortic arch and pulmonary arteries during development
한국실험동물학회 학술발표대회 논문집
2018 .01
-
CXCL12-CXCR4 Promotes Proliferation and Invasion of Pancreatic Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
여포성 종양에서 CXC Chemokine Receptor 4와 Galectin-3의 면역조직화학적 발현
International Journal of Thyroidology
2012 .01
-
The CXCR4 Antagonist AMD3100 Has Dual Effects on Survival and Proliferation of Myeloma Cells In Vitro
Cancer Research and Treatment
2010 .01
-
WHIM Syndrome With a Novel CXCR4 Variant in a Korean Child
Annals of Laboratory Medicine
2017 .01
-
진행성 자궁내막증 환자의 자궁내막에서 추정줄기세포의 과다발현
Obstetrics & Gynecology Science
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0